D-473
D-473 is an orally active, blood-brain barrier-penetrant reuptake inhibitor with a preference for serotonin. D-473 inhibits the serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET), significantly elevating the extracellular levels of these three neurotransmitters in rat brain regions. D-473 exhibits clear antidepressant-like activity without inducing motor activation. D-473 is widely used in research related to major depressive disorder.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1632000-05-5
- 分子式: C26H27F2NO3
- 分子量:439.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
D-473 (25 mg/kg; p.o.; single dose) does not significantly alter locomotor activity in rats[1].
D-473 (10 mg/kg; i.p.; single dose) significantly elevates extracellular dopamine, serotonin, and norepinephrine in the rat mPFC and DLS, while reducing levels of dopamine metabolites in these regions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rat with major depressive disorder (male, 200-225 g)[1]
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Dosage:5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg
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Administration:p.o.; single dose; 1 hour prior to 5-minute swim test
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Result:Produced no significant reduction in immobility time at 5 mg/kg.
Reduced immobility time significantly compared to vehicle at 10 mg/kg.
Reduced immobility time significantly compared to vehicle at 25 mg/kg.
Reduced immobility time significantly compared to vehicle at 50 mg/kg.
化学情報
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CAS 番号 1632000-05-5
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分子量 439.49
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分子式 C26H27F2NO3
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SMILES
O[C@@H]([C@@H](CO1)NCC2=CC=C(C=C2)OC)C[C@H]1C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
D-473 関連分類
HY-182247 関連分類
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