D-Ala-D-Ala
Based on 1 Customer Validation
D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 923-16-0
- 分子式: C6H12N2O3
- 分子量:160.17
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Antibacterial Compound Library
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Amino Acid Metabolite Compound Library
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Natural Product and Natural Product-Like Compound Library
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Microbial Metabolite |
D-Ala-D-Ala (15 mM) shows a 30% decrease in the GRABS score for the dadA::Tn mutant[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 923-16-0
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性状 Solid
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分子量 160.17
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分子式 C6H12N2O3
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Color White to off-white
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別名
D-Alanyl-D-alanine; H-D-Ala-D-Ala-OH
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 100 mg/mL (624.34 mM; Need ultrasonic)
DMSO : 2 mg/mL (12.49 mM; ultrasonic and adjust pH to 5 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
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- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kitamura Y, et al. Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1098-106. [Content Brief]
[2]. Tytgat I, et al. DD-ligases as a potential target for antibiotics: past, present and future. Curr Med Chem. 2009;16(20):2566-80. [Content Brief]
[3]. Trivedi RR, et al. Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness. mBio. 2018 Sep 11;9(5):e01340-18. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 6.2434 mL | 31.2168 mL | 62.4337 mL | 156.0842 mL |
| 5 mM | 1.2487 mL | 6.2434 mL | 12.4867 mL | 31.2168 mL | |
| 10 mM | 0.6243 mL | 3.1217 mL | 6.2434 mL | 15.6084 mL | |
| H2O | 15 mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 10.4056 mL |
| 20 mM | 0.3122 mL | 1.5608 mL | 3.1217 mL | 7.8042 mL | |
| 25 mM | 0.2497 mL | 1.2487 mL | 2.4973 mL | 6.2434 mL | |
| 30 mM | 0.2081 mL | 1.0406 mL | 2.0811 mL | 5.2028 mL | |
| 40 mM | 0.1561 mL | 0.7804 mL | 1.5608 mL | 3.9021 mL | |
| 50 mM | 0.1249 mL | 0.6243 mL | 1.2487 mL | 3.1217 mL | |
| 60 mM | 0.1041 mL | 0.5203 mL | 1.0406 mL | 2.6014 mL | |
| 80 mM | 0.0780 mL | 0.3902 mL | 0.7804 mL | 1.9511 mL | |
| 100 mM | 0.0624 mL | 0.3122 mL | 0.6243 mL | 1.5608 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Ala-D-Ala 関連分類
HY-W015450 関連分類
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