DB772 hydrate
Based on 1 publication(s) in Google Scholar
DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.89%
- 分子式: C20H19ClN4O2
- 分子量:502.54
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 DB772 hydrate
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生物活性
製品説明
体外実験
DB772 hydrate (0-100 μM, 96 hours) can inhibit replication of the viruses BVDV2 and BDV at concentrations greater than 0.2 μM, Bungowannah virus replication at concentrations greater than 0.01 μM, and HoBi virus replication greater than 1.65 μM[2].
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DB772 hydrate has antiprion activity with CC50 (50% cytotoxic concentration) value of 3.8 μM, TC-EC50 (50% tissue culture effective concentration) value of 0. 8 μM and inhibits PrPSc accumulation in sheep microglia[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:PrPSc-positive and -negative cell lines of human telomerase-immortalized (hTERT) ovine microglia
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Concentration:1 μM
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Incubation Time:4 days
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Result:Showed no significant effect on cell viability with 96.4% cell viability.
Significantly reduced PrPSc-positive spots by 65.8% and completely inhibited PrPSc accumulation in scrapie-infected primary ovine microglia at 4 μM.
化学情報
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性状 Solid
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分子量 502.54
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分子式 C20H19ClN4O2
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Color Light yellow to yellow
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SMILES
[H]Cl.C1(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)=NC5=CC=CC=C5N1.[2.8].[4].O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : ≥ 4 mg/mL (7.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. [Content Brief]
[2]. Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96(2):127-9. [Content Brief]
[3]. Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9899 mL | 9.9495 mL | 19.8989 mL | 49.7473 mL |
| 5 mM | 0.3980 mL | 1.9899 mL | 3.9798 mL | 9.9495 mL |
DB772 hydrate 関連分類
HY-114621A 関連分類
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