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製品番号: HY-185694

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DBCO2-SS2-PEG24

DBCO2-SS2-PEG24 is a bivalent shielding agent containing dibenzocyclooctyne (DBCO) and PEG24 domains, synthesized for copper-free click reaction-mediated postmodification of azide-bearing siRNA lipo-polyplexes.DBCO2-SS2-PEG24 can be used for the research of cervical carcinoma, hepatocellular carcinoma.

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CAS 番号: 2304536-81-8
分子式: C₁₁₃H₁₇₃N₉O₃₅S₄
分子量:2345.88

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DBCO2-SS2-PEG24 構造式

CAS 番号: 2304536-81-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

DBCO₂-SS2-PEG₂₄ (0.25-1 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes maintain stable spherical morphology, provide effective charge shielding, exhibit good serum stability, and mediate moderate gene silencing in EGFR-overexpressing KB/eGFPLuc and Huh7/eGFPLuc cells^[1].
DBCO₂-SS2-PEG₂₄ (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes exhibit lower cellular internalization efficiency in EGFR-overexpressing KB and Huh7 cells compared to GE11-targeted DBCO-modified polyplexes^[1].
DBCO₂-SS2-PEG₂₄ (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes mediate moderate EG5 gene silencing and antitumoral activity in EGFR-overexpressing KB and Huh7 cells, with lower efficacy than GE11-targeted DBCO-modified polyplexes^[1].
DBCO₂-SS2-PEG₂₄ (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes induce moderate EG5 silencing-related mitotic arrest and apoptosis in EGFR-overexpressing KB and Huh7 cells, with lower potency than GE11-targeted DBCO-modified polyplexes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2304536-81-8
分子量 2345.88
分子式 C₁₁₃H₁₇₃N₉O₃₅S₄
SMILES

O=C(CCC(NCCSSCCCNC(CCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)CCCCNC(CCC(NCCCSSCCNC(CCC(N1CC2=CC=CC=C2C#CC3=CC=CC=C31)=O)=O)=O)=O)=O)=O)=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wang Y, et al. Double Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells. ACS Biomater Sci Eng. 2020;6(2):1074-1089. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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