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製品番号: HY-169013

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DDO-3733

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates.

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CAS 番号: 2923531-63-7
分子式: C₁₀H₆F₂N₂OS
分子量:240.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DDO-3733 構造式

CAS 番号: 2923531-63-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	40.79 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM)	[PMID: 39145509]
SW-620	IC₅₀	54.41 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM)	[PMID: 39145509]

化学情報

CAS 番号 2923531-63-7
分子量 240.23
分子式 C₁₀H₆F₂N₂OS
SMILES

S=C(C1=CC2=C(F)C=C(F)C=C2OC1=N)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhang Q, et al. Allosteric Activation of Protein Phosphatase 5 with Small Molecules. J Med Chem. 2024 Sep 12;67(17):15080-15097. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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