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製品番号: HY-183972

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Desaspidin

Desaspidin is an oxidative phosphorylation inhibitor and photophosphorylation inhibitor. Desaspidin uncouples mitochondrial oxidative phosphorylation, multiple chloroplast photophosphorylation pathways, and ATP synthesis linked to non-cyclic NADP reduction. Desaspidin can be used for the research of anthelmintic agent.

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CAS 番号: 114-43-2
分子式: C₂₄H₃₀O₈
分子量:446.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Desaspidin 構造式

CAS 番号: 114-43-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Desaspidin (0.5-2.0 μM; 2 min) uncouples photophosphorylation in isolated spinach chloroplasts, with an IC₅₀ of ~0.5 μM for X_E accumulation, reducing X_E half-life and ATP yield in a concentration-dependent manner^[1].
Desaspidin (1.1 μM; 0.25-20 min) inhibits FMN-catalysed photophosphorylation in isolated spinach chloroplasts completely at short illumination times^[1].
Desaspidin (0.1-5 μM) uncouples ferredoxin-catalysed cyclic photophosphorylation in isolated spinach chloroplasts with an IC₅₀ of ~0.2 μM^[1].
Desaspidin (100 nM-10 μM) acts as a potent, redox-dependent uncoupler of photophosphorylation in swiss chard, spinach, or lettuce chloroplasts^[2].
Desaspidin (5 μM) initially uncouples FMN-driven photophosphorylation in swiss chard, spinach, or lettuce chloroplasts, but its inhibitory activity is lost over time due to photodestruction, with resistance reduced at lower chlorophyll concentrations^[2].
Desaspidin (0.5 μM; 10 minutes) strongly inhibits both cyclic and noncyclic (reduced dichlorophenol indophenol-to-TPN) photophosphorylation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 114-43-2
分子量 446.49
分子式 C₂₄H₃₀O₈
SMILES

O=C1C(C(CCC)=O)=C(C(C)(C)C(O)=C1CC2=C(C(C(CCC)=O)=C(C=C2OC)O)O)O
Structure Classification
- Phenylpropanoids
- Other Phenylpropanoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hind G. Effect of desaspidin on photosynthetic phosphorylation and related processes. Nature. 1966 May 14;210(5037):703-8. [Content Brief]

[2]. Gromet-Elhanan Z, et al. Desaspidin: a nonspecific uncoupler of photophosphorylation. Plant Physiol. 1966 Sep;41(7):1231-6. [Content Brief]

[3]. Gromet-Elhanan Z, et al. Effect of desaspidin on photosynthetic phosphorylation. Plant Physiol. 1965 Nov;40(6):1060-5. [Content Brief]

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