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製品番号: HY-DY1111

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DFHBI-2T (solution)

DFHBI-2T solution is a membrane-permeable, RNA aptamer-activated fluorescent probe (Ex/Em=500 nm/523 nm), with a K_d value of 1300 nM for the RNA aptamer Spinach2. DFHBI-2T solution binds to Spinach2, converting the fluorophore to a fluorescent state, stabilizing its planar structure to facilitate the radiative fluorescence decay pathway, and forming a complex with red-shifted excitation and emission peaks. DFHBI-2T solution can be used for RNA imaging in live cells. It is also applicable to research related to fragile X-associated tremor/ataxia syndrome.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1539318-40-5
分子式: C₁₂H₇F₅N₂O₂
分子量:306.19

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DFHBI-2T (solution) 構造式

CAS 番号: 1539318-40-5

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

DFHBI-2T solution (1 μM) binds Spinach2 RNA aptamer with a K_d of 1300 nM, forming a complex with excitation maximum at 500 nm, emission maximum at 523 nm^[1].
DFHBI-2T solution (20 μM; 10 min) forms a fluorescent complex that is readily detectable using a YFP filter cube but not a GFP filter cube in COS7 cells expressing (CGG)₆₀-Spinach2^[1].
DFHBI-2T solution enables SAM-dependent fluorescence detection at 523 nm using a Spinach2-based SAM sensor in vitro^[1].
DFHBI-2T solution binds to the Spinach2 RNA aptamer with a K_d of 1300 nM, exhibiting a shift in spectral properties and a 60-fold increase in brightness compared to its free state^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1539318-40-5
分子量 306.19
分子式 C₁₂H₇F₅N₂O₂
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Song W, et al. Plug-and-play fluorophores extend the spectral properties of Spinach. Journal of the American Chemical Society. 2014 Jan 29;136(4):1198-201. [Content Brief]

[2]. Ouellet J, et al. RNA Fluorescence with Light-Up Aptamers. Frontiers in chemistry. 2016;4:29.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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