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製品番号: HY-P99853

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Biologically Validated

Diridavumab

Name: Diridavumab
Brand: MedChemExpress
SKU: HY-P99853
Price: 350.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: CR6261)

カスタマーレビュー

Based on 1 Customer Validation

Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 98.00%
CAS 番号: 1393659-46-5
分子量:144.2 kDa

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Diridavumab 構造式

CAS 番号: 1393659-46-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Verified Bioactivity
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isotype

Human IgG1 lambda2

Recommend Isotype Controls

Human IgG1 lambda2, Isotype Control

Species Reactivity

Virus

IC₅₀ & Target

influenza A virus hemagglutinin HA

体外実験

Diridavumab (CR6261; 500 μg/mL) neutralized AA60 and Sw06 with 39.4 μg/mL and 176.8μg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; BALB/c mice with H2 influenza virus) protects mice against lethal H2 influenza virus in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice with H2 influenza virus^[1]
Dosage:

1.7, 5, or 15 mg/kg
Administration:

Intraperitoneal injection
Result:

Prevented mortality and decreased the percent weight loss.
Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

アクセッション番号

C3W5S1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 lambda2

アプリケーション

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized HA/Hemagglutinin Protein, H1N1 can bind Diridavumab. The EC₅₀ for this effect is 5.645 ng/mL.
Loaded Diridavumab on ProA biosensor, can bind HA/Hemagglutinin Protein, H1N1 (sf9, His, HY-P72800) with an affinity constant of 5.484E-09 M as determined in BLI assay.

化学情報

CAS 番号 1393659-46-5
性状 Liquid
分子量 144.2 kDa
Color Colorless to light yellow
SMILES

[Diridavumab]
別名

CR6261
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Sutton TC, et, al. In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice. J Virol. 2017 Nov 30;91(24):e01603-17. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
- Biological Activity
化学情報
純度とドキュメンテーション
参考文献

1/16

Human IgG1 lambda2
1/16

Immobilized HA/Hemagglutinin Protein, H1N1 can bind Diridavumab. The EC₅₀ for this effect is 5.645 ng/mL.
1/16

Loaded Diridavumab on ProA biosensor, can bind HA/Hemagglutinin Protein, H1N1 (sf9, His, HY-P72800) with an affinity constant of 5.484E-09 M as determined in BLI assay.
1/16

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Diridavumab

Protein A Agarose

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)