DOCK2-IN-1
Based on 1 Customer Validation
DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.37%
- CAS 番号: 4590-86-7
- 分子式: C16H11ClN2O2
- 分子量:298.72
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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DOCK2 19.1 μM (IC50) |
DOCK2-IN-1 (0.1-100 μM; 2-30 min) potently inhibits the Rac1 guanine nucleotide exchange factor activity of purified DOCK2DHR-2 protein, with an IC50 of 19.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 4590-86-7
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性状 Solid
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分子量 298.72
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分子式 C16H11ClN2O2
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Color Brown to reddish brown
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SMILES
O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (334.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3476 mL | 16.7381 mL | 33.4762 mL | 83.6904 mL |
| 5 mM | 0.6695 mL | 3.3476 mL | 6.6952 mL | 16.7381 mL | |
| 10 mM | 0.3348 mL | 1.6738 mL | 3.3476 mL | 8.3690 mL | |
| 15 mM | 0.2232 mL | 1.1159 mL | 2.2317 mL | 5.5794 mL | |
| 20 mM | 0.1674 mL | 0.8369 mL | 1.6738 mL | 4.1845 mL | |
| 25 mM | 0.1339 mL | 0.6695 mL | 1.3390 mL | 3.3476 mL | |
| 30 mM | 0.1116 mL | 0.5579 mL | 1.1159 mL | 2.7897 mL | |
| 40 mM | 0.0837 mL | 0.4185 mL | 0.8369 mL | 2.0923 mL | |
| 50 mM | 0.0670 mL | 0.3348 mL | 0.6695 mL | 1.6738 mL | |
| 60 mM | 0.0558 mL | 0.2790 mL | 0.5579 mL | 1.3948 mL | |
| 80 mM | 0.0418 mL | 0.2092 mL | 0.4185 mL | 1.0461 mL | |
| 100 mM | 0.0335 mL | 0.1674 mL | 0.3348 mL | 0.8369 mL |
DOCK2-IN-1 関連分類
HY-153128 関連分類
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