DOPE-PEG2000-APRPG
DOPE-PEG2000-APRPG (DOPE-PEG2000-Mal-Cys-APRPG) is an amphiphilic lipid-PEG-peptide conjugate consisting of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the APRPG peptide (Ala-Pro-Arg-Gly), a tumor-homing peptide. DOPE-PEG2000-APRPG is used for tumor vasculature-targeted drug delivery.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
生物活性
DOPE-PEG2000-APRPG: surface modification of liposomes and nanoparticles for tumor vasculature-targeted drug delivery and anti-angiogenic research in cancer treatment.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-dependent membrane fusion for intracellular drug release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization and immune clearance, and extends blood circulation half-life;
(3) APRPG peptide; a tumor-homing tetrapeptide that specifically binds to aminopeptidase N (CD13), a cell-surface enzyme highly expressed on angiogenic endothelial cells in tumor vasculature but not on normal blood vessels, enabling selective targeting of tumor neovasculature for anti-angiogenic drug delivery.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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SMILES
[DOPE-PEG2000-APRPG]
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別名
DOPE-PEG2000-Mal-Cys-APRPG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DOPE-PEG2000-APRPG 関連分類
HY-187410A 関連分類
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