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製品番号: HY-126773

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Dp2mT

Dp2mT is a non-cytotoxic control compound, with an IC₅₀ of >3 μM for HIV-1 transcription inhibition and an IC₅₀ of >10 μM for cytotoxicity. Dp2mT does not bind to intracellular iron pools. Dp2mT does not inhibit CDK9 activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 741250-22-6
分子式: C₁₃H₁₃N₅S
分子量:271.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dp2mT 構造式

CAS 番号: 741250-22-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Dp2mT (24 h) has the IC₅₀ >3 μM against HIV-1 transcription in CEM-GFP cells^[1].
Dp2mT (24 h) shows no cytotoxicity in CEM T cells, with an IC₅₀ >10 μM^[1].
Dp2mT (10 μM; 24 h) does not inhibit CDK9 kinase activity in 293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

CEM T cells
Concentration:

/
Incubation Time:

24 h
Result:

Showed no cytotoxicity to CEM T cells after 24 h of incubation, with an IC₅₀ greater than 10 μM.

Related Protocols :

化学情報

CAS 番号 741250-22-6
分子量 271.34
分子式 C₁₃H₁₃N₅S
SMILES

S=C(N)N(N=C(C1=NC=CC=C1)C2=NC=CC=C2)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Debebe Z, et al. Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Mol Pharmacol. 2011;79(1):185-196. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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