DS-5272
DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice.
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- CAS 番号: 1235575-97-9
- 分子式: C34H38Cl2F2N6O2S
- 分子量:703.67
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 20 nM (p53-MDM2 interaction)
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | GI50 |
>50 μM
Compound: 8, DS-5272
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Antiproliferative activity against human DLD1 cells expressing mutant p53 after 3 days by luminescent cell viability assay
Antiproliferative activity against human DLD1 cells expressing mutant p53 after 3 days by luminescent cell viability assay
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[PMID: 25882531] |
| SJSA-1 | GI50 |
0.17 μM
Compound: 8, DS-5272
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Antiproliferative activity against human SJSA1 cells expressing wildtype p53 after 3 days by luminescent cell viability assay
Antiproliferative activity against human SJSA1 cells expressing wildtype p53 after 3 days by luminescent cell viability assay
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[PMID: 25882531] |
化学情報
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CAS 番号 1235575-97-9
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分子量 703.67
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分子式 C34H38Cl2F2N6O2S
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SMILES
O=C([C@H]1N(C(C2=C(C(C)C)N3C(S2)=N[C@@](C)(C4=CC=C(Cl)N=C4)[C@H]3C5=CC=C(Cl)C(F)=C5)=O)C[C@H](F)C1)N(C6)[C@H](CC)CNC76CC7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DS-5272 関連分類
HY-120667 関連分類
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