Dynole 2−24
Based on 1 publication(s) in Google Scholar
Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis
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- 純度: 99.07%
- CAS 番号: 1416313-72-8
- 分子式: C24H41N3
- 分子量:371.60
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Dynole 2−24
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | IC50 |
1.9 μM
Compound: 24
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Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins
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[PMID: 23167654] |
化学情報
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CAS 番号 1416313-72-8
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性状 Oil
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分子量 371.60
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分子式 C24H41N3
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Color Colorless to light yellow
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SMILES
CN(C)CCCN1C=C(CNCCCCCCCCCC)C2=C1C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Environ Health (Wash)
The Constituent-Dependent Translocation Mechanism for PM2.5 to Travel through the Olfactory Pathway. [Abstract]2024 Oct 1;2(12):856-864. PMID: 39722842
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (269.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6911 mL | 13.4553 mL | 26.9107 mL | 67.2766 mL |
| 5 mM | 0.5382 mL | 2.6911 mL | 5.3821 mL | 13.4553 mL | |
| 10 mM | 0.2691 mL | 1.3455 mL | 2.6911 mL | 6.7277 mL | |
| 15 mM | 0.1794 mL | 0.8970 mL | 1.7940 mL | 4.4851 mL | |
| 20 mM | 0.1346 mL | 0.6728 mL | 1.3455 mL | 3.3638 mL | |
| 25 mM | 0.1076 mL | 0.5382 mL | 1.0764 mL | 2.6911 mL | |
| 30 mM | 0.0897 mL | 0.4485 mL | 0.8970 mL | 2.2426 mL | |
| 40 mM | 0.0673 mL | 0.3364 mL | 0.6728 mL | 1.6819 mL | |
| 50 mM | 0.0538 mL | 0.2691 mL | 0.5382 mL | 1.3455 mL | |
| 60 mM | 0.0449 mL | 0.2243 mL | 0.4485 mL | 1.1213 mL | |
| 80 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8410 mL | |
| 100 mM | 0.0269 mL | 0.1346 mL | 0.2691 mL | 0.6728 mL |
Dynole 2−24 関連分類
HY-145080 関連分類
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