EAPB 02303
Based on 1 Customer Validation
EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.05%
- CAS 番号: 1958290-51-1
- 分子式: C17H14N4O2
- 分子量:306.32
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Cytoskeleton Compound Library
HY-L060
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Anti-Lung Cancer Compound Library
HY-L075
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Protein-protein Interaction Inhibitor Library
HY-L109
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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High-Efficiency Gene Editing Compound Library
HY-L244
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2058 | IC50 |
4 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
| A-375 | IC50 |
3 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
| IPC-298 | IC50 |
40 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
| MeWo | IC50 |
3 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
化学情報
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CAS 番号 1958290-51-1
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性状 Solid
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分子量 306.32
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分子式 C17H14N4O2
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Color Light yellow to yellow
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SMILES
OC(C=C1)=C(O)C=C1C2=CN=C3C(NC)=NC4=CC=CC=C4N32
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
H2O : 30 mg/mL (97.94 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2646 mL | 16.3228 mL | 32.6456 mL | 81.6140 mL |
| 5 mM | 0.6529 mL | 3.2646 mL | 6.5291 mL | 16.3228 mL | |
| 10 mM | 0.3265 mL | 1.6323 mL | 3.2646 mL | 8.1614 mL | |
| 15 mM | 0.2176 mL | 1.0882 mL | 2.1764 mL | 5.4409 mL | |
| 20 mM | 0.1632 mL | 0.8161 mL | 1.6323 mL | 4.0807 mL | |
| 25 mM | 0.1306 mL | 0.6529 mL | 1.3058 mL | 3.2646 mL | |
| 30 mM | 0.1088 mL | 0.5441 mL | 1.0882 mL | 2.7205 mL | |
| 40 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 50 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL | 1.6323 mL | |
| 60 mM | 0.0544 mL | 0.2720 mL | 0.5441 mL | 1.3602 mL | |
| 80 mM | 0.0408 mL | 0.2040 mL | 0.4081 mL | 1.0202 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
EAPB 02303 関連分類
HY-153384 関連分類
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