Edonentan
Based on 1 Customer Validation
Edonentan (BMS 207940) is an antagonist for endothelin receptor (ETA receptor), with a Ki of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.13%
- CAS 番号: 210891-04-6
- 分子式: C28H32N4O5S
- 分子量:536.64
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
ETA 10 pM (Ki) |
ETB 810 nM (Ki) |
化学情報
-
CAS 番号 210891-04-6
-
性状 Solid
-
分子量 536.64
-
分子式 C28H32N4O5S
-
Color White to light yellow
-
SMILES
CC(C)(C)CC(N(CC1=CC(C2=NC=CO2)=CC=C1C3=CC=CC=C3S(=O)(NC4=NOC(C)=C4C)=O)C)=O
-
別名
BMS 207940
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 55 mg/mL (102.49 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Murugesan N, et al., Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003 Jan 2;46(1):125-37. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8634 mL | 9.3172 mL | 18.6345 mL | 46.5862 mL |
| 5 mM | 0.3727 mL | 1.8634 mL | 3.7269 mL | 9.3172 mL | |
| 10 mM | 0.1863 mL | 0.9317 mL | 1.8634 mL | 4.6586 mL | |
| 15 mM | 0.1242 mL | 0.6211 mL | 1.2423 mL | 3.1057 mL | |
| 20 mM | 0.0932 mL | 0.4659 mL | 0.9317 mL | 2.3293 mL | |
| 25 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.8634 mL | |
| 30 mM | 0.0621 mL | 0.3106 mL | 0.6211 mL | 1.5529 mL | |
| 40 mM | 0.0466 mL | 0.2329 mL | 0.4659 mL | 1.1647 mL | |
| 50 mM | 0.0373 mL | 0.1863 mL | 0.3727 mL | 0.9317 mL | |
| 60 mM | 0.0311 mL | 0.1553 mL | 0.3106 mL | 0.7764 mL | |
| 80 mM | 0.0233 mL | 0.1165 mL | 0.2329 mL | 0.5823 mL | |
| 100 mM | 0.0186 mL | 0.0932 mL | 0.1863 mL | 0.4659 mL |
Edonentan 関連分類
HY-15402 関連分類
Powered by Bioz