ES9-17
Based on 1 publication(s) in Google Scholar
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.68%
- CAS 番号: 55854-43-8
- 分子式: C10H8BrNO2S2
- 分子量:318.21
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 ES9-17
More
生物活性
ES9-17 (0-100 μM; 30 min) inhibits the uptake of the lipophilic styryl endocytic tracer dye (FM4-64), with an EC50 value of 13 μM[1].
ES9-17 (30 μM; 30 min) doesn’t deplete cellular ATP[1].
ES9-17 (30 μM; 30 min) also reduces the uptake of transferrin in HeLa cells[1].
ES9-17 targets to CHC and mediates transport of materials among organelles without causing cytoplasmic acidification[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 55854-43-8
-
性状 Solid
-
分子量 318.21
-
分子式 C10H8BrNO2S2
-
Color White to off-white
-
SMILES
O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
2024 Apr 23;15(1):3437. PMID: 38653755
溶剤 & 溶解度
DMSO : 125 mg/mL (392.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15(6):641-649. [Content Brief]
[2]. Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1426 mL | 15.7129 mL | 31.4258 mL | 78.5645 mL |
| 5 mM | 0.6285 mL | 3.1426 mL | 6.2852 mL | 15.7129 mL | |
| 10 mM | 0.3143 mL | 1.5713 mL | 3.1426 mL | 7.8564 mL | |
| 15 mM | 0.2095 mL | 1.0475 mL | 2.0951 mL | 5.2376 mL | |
| 20 mM | 0.1571 mL | 0.7856 mL | 1.5713 mL | 3.9282 mL | |
| 25 mM | 0.1257 mL | 0.6285 mL | 1.2570 mL | 3.1426 mL | |
| 30 mM | 0.1048 mL | 0.5238 mL | 1.0475 mL | 2.6188 mL | |
| 40 mM | 0.0786 mL | 0.3928 mL | 0.7856 mL | 1.9641 mL | |
| 50 mM | 0.0629 mL | 0.3143 mL | 0.6285 mL | 1.5713 mL | |
| 60 mM | 0.0524 mL | 0.2619 mL | 0.5238 mL | 1.3094 mL | |
| 80 mM | 0.0393 mL | 0.1964 mL | 0.3928 mL | 0.9821 mL | |
| 100 mM | 0.0314 mL | 0.1571 mL | 0.3143 mL | 0.7856 mL |
ES9-17 関連分類
HY-131683 関連分類
Powered by Bioz