FB23
Based on 2 publication(s) in Google Scholar
FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
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- 純度: 98.88%
- CAS 番号: 2243736-35-6
- 分子式: C18H14Cl2N2O3
- 分子量:377.22
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 FB23
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生物活性
IC50: 60 nM (FTO)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NB-4 | IC50 |
44.8 μM
Compound: FB23
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Antiproliferative activity against human NB4 cells measured after 72 hrs by celltiter96 aqueous non-radioactive cell proliferation assay
Antiproliferative activity against human NB4 cells measured after 72 hrs by celltiter96 aqueous non-radioactive cell proliferation assay
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[PMID: 37974948] |
FB23 (72 hours) treatment inhibits acute myeloid leukemia (AML) cells proliferation with IC50 values of 44.8 μM, 23.6 μM for NB4 and MONOMAC6 AML cells[1].
FB23 treatment causes the significant suppression of MYC targets, E2F targets, and G2M checkpoint signal cascades, which may contribute to the inhibitory effects of FTO inhibitors and FTO KD on cell cycle and proliferation. FB23 treatments activates apoptosis and p53 pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2243736-35-6
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性状 Solid
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分子量 377.22
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分子式 C18H14Cl2N2O3
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Color White to off-white
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SMILES
O=C(O)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m6A modification. [Abstract]2024 Jun 17;15(6):422. PMID: 38886389 -
Res Sq
2025 Nov 4:rs.3.rs-7958216. PMID: 41282238
溶剤 & 溶解度
DMSO : 125 mg/mL (331.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6510 mL | 13.2549 mL | 26.5097 mL | 66.2743 mL |
| 5 mM | 0.5302 mL | 2.6510 mL | 5.3019 mL | 13.2549 mL | |
| 10 mM | 0.2651 mL | 1.3255 mL | 2.6510 mL | 6.6274 mL | |
| 15 mM | 0.1767 mL | 0.8837 mL | 1.7673 mL | 4.4183 mL | |
| 20 mM | 0.1325 mL | 0.6627 mL | 1.3255 mL | 3.3137 mL | |
| 25 mM | 0.1060 mL | 0.5302 mL | 1.0604 mL | 2.6510 mL | |
| 30 mM | 0.0884 mL | 0.4418 mL | 0.8837 mL | 2.2091 mL | |
| 40 mM | 0.0663 mL | 0.3314 mL | 0.6627 mL | 1.6569 mL | |
| 50 mM | 0.0530 mL | 0.2651 mL | 0.5302 mL | 1.3255 mL | |
| 60 mM | 0.0442 mL | 0.2209 mL | 0.4418 mL | 1.1046 mL | |
| 80 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8284 mL | |
| 100 mM | 0.0265 mL | 0.1325 mL | 0.2651 mL | 0.6627 mL |
FB23 関連分類
HY-137187 関連分類
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