FG-3019
Based on 2 publication(s) in Google Scholar
FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: ≥99.0%
- CAS 番号: 946415-13-0
- 分子量:144.86 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 FG-3019
More-
WB
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Histological Imaging/Staining
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CTGF
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized CCN2/CTGF Protein, Human can bind Pamrevlumab . The EC50 for this effect is 6.731 ng/mL.
化学情報
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CAS 番号 946415-13-0
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性状 Liquid
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分子量 144.86 kDa
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Color Colorless to light yellow
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SMILES
[FG-3019]
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別名
Pamrevlumab; Anti-Human CTGF Recombinant Antibody
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models. [Abstract]2025 Sep 30;16(1):8710. PMID: 41027873 -
FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.
Wild-type (WT) mice were treated with PBS, and Mdx mice were treated with PBS, FG-3019 (50 mg/kg), TGF-β1 antibody (TGF-β1 ab), FG-3019 + TGF-β1 antibody (CTGF + F + T), and IgG for 6 weeks. Western blot analysis of myofibril and collagen III levels was then performed.
FG-3019 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2026 Feb 26.
Masson staining was used to detect the diaphragm of wild-type (WT) mice treated with PBS, and mdx mice treated with PBS, Apc003OA, FG-3019 (50 mg/kg), Apc003OA+BP, and BP.
純度とドキュメンテーション
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データシート (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777. [Content Brief]
[2]. Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)