Finerenone (Standard)
Based on 1 Customer Validation
Finerenone (Standard) is the analytical standard of Finerenone. This product is intended for research and analytical applications. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.59%
- CAS 番号: 1050477-31-0
- 分子式: C21H22N4O3
- 分子量:378.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
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HY-111372
FinerenoneMineralocorticoid Receptor Antagonist -
HY-B0251
EplerenoneAldosterone Blocker -
HY-B0251R
Eplerenone (Standard) -
HY-100471
EsaxerenoneMineralocorticoid Antagonist -
HY-113447
11-DehydrocorticosteroneEndogenous Corticosteroid -
HY-132809
BaxdrostatAldosterone Synthase Inhibitor -
HY-16276
OsilodrostatCYP11B1/CYP11B2 Inhibitor -
HY-109002
ApararenoneMineralocorticoid Receptor Antagonist -
HY-B1203A
Fludrocortisone acetateMineralocorticoid -
HY-B1203AR
Fludrocortisone acetate (Standard) -
HY-100471R
Esaxerenone (Standard)Mineralocorticoid Antagonist -
HY-109002R
Apararenone (Standard)Reference Standard
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 1050477-31-0
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性状 Solid
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分子量 378.42
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分子式 C21H22N4O3
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Color White to off-white
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SMILES
O=C(C1=C(C)NC2=C(C(OCC)=NC=C2C)[C@@H]1C3=CC=C(C#N)C=C3OC)N
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別名
BAY 94-8862 (Standard)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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SDS (788 KB)
- English - EN (788 KB)
- Français - FR (788 KB)
- Deutsch - DE (788 KB)
- Norwegian - NO (788 KB)
- Español - ES (788 KB)
- Swedish - SV (788 KB)
- Italian - IT (788 KB)
- Korean - KR (788 KB)
- Portuguese - PT (788 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Bärfacker L, et al. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem. 2012;7(8):1385-1403. [Content Brief]
[2]. González-Blázquez R, et al. Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress. Front Pharmacol. 2018;9:1131. Published 2018 Oct 9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Finerenone (Standard) 関連分類
HY-111372R 関連分類
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