FiVe1
Based on 1 publication(s) in Google Scholar
FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 932359-76-7
- 分子式: C18H16Cl2N4
- 分子量:359.25
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 FiVe1
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生物活性
IC50: VIM[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| GCT | IC50 |
1686 nM
Compound: FiVe1
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Antiproliferative activity against human GCT cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human GCT cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
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[PMID: 36001933] |
| HT-1080 | IC50 |
1564 nM
Compound: FiVe1
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Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
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[PMID: 36001933] |
| MCF7 | IC50 |
>20000 nM
Compound: FiVe1
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
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[PMID: 36001933] |
| RD | IC50 |
3095 nM
Compound: FiVe1
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Antiproliferative activity against human RD cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
Antiproliferative activity against human RD cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-glo proliferation assay
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[PMID: 36001933] |
FiVe1 (2 μM; 72 h) selectively inhibits the growth of FOXC2-HMLER cells while showing little toxicity to HMLER cells[1].
FiVe1 (250 nM) results in a collapsed VIM filamentous structure in FOXC2-HMLER cells[1].
FiVe1 (1 μM for multinucleation test; 24 h for multinucleation test) inhibits the growth of multiple soft tissue sarcoma (STS) cell lines (HT1080, SW684, RD, GCT, SW872, SW982) and promotes multinucleation in these cell lines, respectively[1].
FiVe1 (72 h) inhibits the growth of HUVECs and human lung fibroblasts (HLFs), with IC50 values of 1.70 μM and 2.32 μM, respectively[1].
FiVe1 inhibits the growth of HT-1080 fibrosarcoma cells, with an IC50 of 1.6 μM[2].
FiVe1 (0.2 μM; 72 h) significantly sensitizes both A2780 and A2780cis cells towards Cisplatin (HY-17394)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 932359-76-7
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性状 Solid
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分子量 359.25
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分子式 C18H16Cl2N4
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Color Light yellow to brown
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SMILES
ClC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Transbound Emerg Dis
2025 Nov 21:2025:5822897. PMID: 41323147
溶剤 & 溶解度
DMSO : 3.6 mg/mL (10.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Michael J Bollong, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. [Content Brief]
[2]. Martínez-Peña F, et al. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15;242:114638. [Content Brief]
[3]. Möltgen S, et al. Cisplatin Protein Binding Partners and Their Relevance for Platinum Drug Sensitivity. Cells. 2020 May 26;9(6):1322. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7836 mL | 13.9179 mL | 27.8358 mL | 69.5894 mL |
| 5 mM | 0.5567 mL | 2.7836 mL | 5.5672 mL | 13.9179 mL | |
| 10 mM | 0.2784 mL | 1.3918 mL | 2.7836 mL | 6.9589 mL |
FiVe1 関連分類
HY-124757 関連分類
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