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製品番号: HY-150794

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FLDP-8

FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC₅₀ value of 4 μM in LN-18 cells.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 861968-02-7
分子式: C₂₂H₂₃NO₅
分子量:381.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

FLDP-8 構造式

CAS 番号: 861968-02-7

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価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC₅₀ value of 4 μM in LN-18 cells^[1].

IC₅₀ & Target

IC50: 4 μM (LN-18 cells)^[1]

体外実験

FLDP-8 (0-40 μM, 24 h) induces cell death process with an IC₅₀ value of 4 μM in a concentration-dependent manner in LN-18 cells, which involves oxidative stress^[1].
FLDP-8 (1.25 μM, 2.5 μM, 24 h) induces significant S-phase cell cycle arrest^[1].
FLDP-8 (2.5 μM, 5 μM, 24 h) exhibits anti-cancer effects with anti-proliferative, anti-migratory and high potency of BBB permeable properties in Glioblastoma multiforme (GBM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LN-18 cells and HBEC‑5i cells
Concentration:

0.625 μM -20 μM (LN‑18 cells) 1.25 μM - 40 μM (HBEC‑5i cells)
Incubation Time:

24 h
Result:

Induced cytotoxicity on LN‑18 cells and HBEC‑5i cells.

Cell Cycle Analysis^[1]

Cell Line:

LN-18 cells
Concentration:

1.25 μM, 2.5 μM
Incubation Time:

24 h
Result:

Induced arrest in S phase in a concentration-dependent manner.

Cell Invasion Assay^[1]

Cell Line:

LN-18 cells
Concentration:

2.5 μM, 5 μM
Incubation Time:

24 h
Result:

Inhibited the invasion of LN‑18 cells.

Cell Migration Assay ^[1]

Cell Line:

LN-18 cells
Concentration:

2.5 μM, 5 μM
Incubation Time:

24 h
Result:

Showed a high potential in inhibiting the migration of LN-18 cells.

化学情報

CAS 番号 861968-02-7
分子量 381.42
分子式 C₂₂H₂₃NO₅
SMILES

O=C1/C(CN(C)C/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Nur Syahirah Che Razali, et al. Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Sci Rep. 2022 Jul 30;12(1):13131. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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