country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-112007

Copy Link Print Information

Fluorosalan

Fluorosalan is an NF-κB inhibitor. Fluorosalan blocks the NF-κB signaling pathway by inhibiting the phosphorylation of IκBα. Fluorosalan induces depolarization of mitochondrial membrane potential in cancer cells and inhibits the growth of various cancer cells. Fluorosalan can be used in studies related to cervical cancer and rheumatoid arthritis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 4776-06-1
分子式: C₁₄H₈Br₂F₃NO₂
分子量:439.03

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fluorosalan 構造式

CAS 番号: 4776-06-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
ME-180	IC50	9.0 μM	Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation. Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation.	20067776
ME-180	IC50	2.7 μM	Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation. Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation.	20067776
ME-180	IC50	1.3 μM	Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation. Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation.	20067776
HeLa	IC50	3.1 μM	Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation. Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation.	20067776
HeLa	IC50	2.1 μM	Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation. Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation.	20067776
HeLa	IC50	3.3 μM	Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation. Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation.	20067776

体外実験

Innate ImmunityCytokines & ChemokinesAnti-cancerApoptosisMitochondrial Function

Innate Immunity

Cytokines & Chemokines

Anti-cancer

Fluorosalan (5 pM-38 μM; 5 h) inhibits the transcriptional activity of NF-κB in TNF-α- and IL-1β-induced NF-κB-bla ME180 human cervical cancer cells, with IC₅₀ values of 7.9 μM and 24.4 μM, respectively^[1].

Innate Immunity

Cytokines & Chemokines

Fluorosalan (5 h) inhibits TNF-α-induced NF-κB transcriptional activity in NF-κB-luc2P HEK293 human embryonic kidney cells, with an IC₅₀ of 25.3 μM^[1].
Fluorosalan (30 min) inhibits TNF-α-induced phosphorylation of IκBα at serine-32 in GFP-IκBα GripTite HEK293 cells, with an IC₅₀ of 2.8 μM^[1].
Fluorosalan (10 μM; 1 h) reduces TNF-α-induced phosphorylation of IκBα at serine-32 in IkB HEK293 cells^[1].

Apoptosis

Fluorosalan (5-24 h) does not induce caspase 3/7 activity in NF-κB-bla ME180 human cervical cancer cells^[1].

Mitochondrial Function

Anti-cancer

Fluorosalan (24 h) depolarizes the mitochondrial membrane potential of ME180 human cervical cancer cells, with an IC₅₀ of 1.2 μM^[1].

Anti-cancer

Fluorosalan (5-72 h) inhibits the viability of ME180 human cervical cancer cells, with IC₅₀ values of 9.0 μM (24 h), 2.7 μM (48 h) and 1.3 μM (72 h)^[1].
Fluorosalan (5-72 h) inhibits the viability of human cervical cancer HeLa cells, with IC₅₀ values of 3.1 μM (24 h), 2.1 μM (48 h) and 3.3 μM (72 h)^[1].

Innate Immunity

Fluorosalan binds to the human IκBα/NF-κB complex (PDB ID: 1IKN) with a maximum binding energy of -8.5 kcal/mol, suggesting that it has potential inhibitory activity against the NF-κB signaling pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

IkB HEK293 cells
Concentration:

10 μM
Incubation Time:

1 h
Result:

Reduced TNF-α-induced IκBα phosphorylation at serine-32.

Related Protocols :

化学情報

CAS 番号 4776-06-1
分子量 439.03
分子式 C₁₄H₈Br₂F₃NO₂
SMILES

O=C(NC1=CC=CC(=C1)C(F)(F)F)C=2C=C(Br)C=C(Br)C2O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Miller SC, et al. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochemical pharmacology. 2010 May 01;79(9):1272-80. [Content Brief]

[2]. Chakraborty D, et al. Potential role of Bavachin in Rheumatoid arthritis: Informatics approach for rational based selection of phytoestrogen[J]. Journal of Herbal Medicine, 2023, 38: 100640.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Fluorosalan

生物活性

製品説明

Cellular Effect

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Fluorosalan 関連分類

HY-112007 関連分類

Bioz

Keywords

最近チェックした製品