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United States

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製品番号: HY-162410

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Fluplatin

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₄₈H₅₆F₂N₄O₈Pt
分子量:1050.06

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Fluplatin 構造式

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity^[1].

体外実験

The IC₅₀ values of Fluplatin against H1975, A549 and A549/DDP cells were 2.24, 4.57 and 4.51 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Fluplatin (10.49 mg/kg, tail vein injection once every three days, a total of 5 times) shows better antitumor activity in H1975 cell subcutaneous tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

H1975 tumor-bearing mouse model^[1]
Dosage:

10.49 mg/kg
Administration:

Tail vein injection, once every three days, a total of 5 times
Result:

Upregulated the expression of cleaved caspase-3.
Reduced the cholesterol level in tumor tissue.

化学情報

分子量 1050.06
分子式 C₄₈H₅₆F₂N₄O₈Pt
SMILES

FC1=CC=C(C=C1)C2=C(N(C3=C2C=CC=C3)C(C)C)/C=C/C(CC(CC(O[Pt]([NH3])(OC(CC(CC(/C=C/C4=C(C5=C(N4C(C)C)C=CC=C5)C6=CC=C(C=C6)F)O)O)=O)[NH3])=O)O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bi YY, et al. Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer. Nat Commun. 2024 Mar 29;15(1):2759. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

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体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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