Junb - jun B proto-oncogene Gene

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 16477

About Junb

Chromosome 8: 85,701,113-85,705,347 reverse strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 236 orthologues, 2 paralogues and is associated with 20 phenotypes.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including decidualization; embryo development; and osteoblast proliferation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor AP-1 complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Used to study systemic lupus erythematosus. Orthologous to human JUNB (JunB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Junb Products (1)

mRNA Protein Name
NM_008416.3 NP_032442.1 transcription factor JunB

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA binding IDA
IDA: Inferred from direct assay
12220541 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
11818961 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
11818961 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19289495 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14610205 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of cell differentiation IDA
IDA: Inferred from direct assay
11456449 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
19303854 MGI
acts upstream of or within decidualization IMP
IMP: Inferred from mutant phenotype
10022836 MGI
acts upstream of or within embryonic process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
10022836 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10022836 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
10022836 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
14769860 MGI
acts upstream of or within osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
14769860 MGI
acts upstream of or within osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
14769860 MGI
acts upstream of or within osteoclast proliferation IMP
IMP: Inferred from mutant phenotype
14769860 MGI
acts upstream of or within positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
11456449 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11818961 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11818961 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
11818961 MGI
acts upstream of or within trophectodermal cell differentiation IDA
IDA: Inferred from direct assay
11456449 MGI
acts upstream of or within trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
10022836 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
10022836 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Junb Protein Structure

Jun

Jun: pfam03957 (5 - 252)

bZIP_Jun

bZIP_Jun: cd14696 (266 - 325)

bZIP_Jun

bZIP_Jun: cd14696 (267 - 318)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

transcription factor JunB

  • Jun-B oncogene

  • myD21

  • transcription factor AP-1 subunit JunB

  • transcription factor jun-B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-W011927 4,4'-Sulfonyldiphenol 99.81% Unkown
HY-W011927S 4,4'-Sulfonyldiphenol-d8 99.21% Unkown
HY-RS07058 Junb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07057 JUNB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07059 Junb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12025 RNASEH2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W092110 Phe-Tyr Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Junb NCBI NCBI:3726