NCS1 - neuronal calcium sensor 1 Gene

Also Known as FLUP; FREQ

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 23413

About NCS1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:130,172,404-130,237,303 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 14 paralogues. Biased expression in brain (RPKM 60.4), esophagus (RPKM 14.4) and 11 other tissues.

Summary

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for Calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCS1 Products (2)

mRNA Protein Name
NM_001128826.2 NP_001122298.1 neuronal calcium sensor 1 isoform 2
NM_014286.4 NP_055101.2 neuronal calcium sensor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
12783849 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
12783849 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12783849 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCS1 Protein Structure

EF-hand_1

EF-hand_1: EF hand (68 - 90)

EF-hand_7

EF-hand_7: EF-hand domain pair (100 - 171)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

neuronal calcium sensor 1

  • frequenin homolog

NCS1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
NCS1 P62166 NBL1 Homo sapiens P41271
Validated Y2H
25416956
Intra
NCS1 P62166 CEP89 Homo sapiens Q96ST8-3
Validated Y2H
32296183
Intra
NCS1 P62166 CEP89 Homo sapiens Q96ST8-3
MAPPIT
32296183
Intra
NCS1 P62166 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 CTAG1A Homo sapiens P78358
Validated Y2H
32296183
Intra
NCS1 P62166 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
NCS1 P62166 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra
NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Validated Y2H
32296183
Intra
NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Y2H Array
32296183
Intra
NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 LY6G6D Homo sapiens O95868
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 LY6G6D Homo sapiens O95868
Y2H Array
32296183
Intra
NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Validated Y2H
32296183
Intra
NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
Intra
NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 SIGLEC9 Homo sapiens Q9Y336
Validated Y2H
32296183
Intra
NCS1 P62166 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra
NCS1 P62166 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 CREM Homo sapiens Q03060-25
Validated Y2H
32296183
Intra
NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
NCS1 P62166 RNASEH1 Homo sapiens O60930
Y2H Array
32296183
Intra
NCS1 P62166 RNASEH1 Homo sapiens O60930
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Y2H Array
32296183
Intra
NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Validated Y2H
32296183
Intra
NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra
NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
32296183
Intra
NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Validated Y2H
32296183
Intra
NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Y2H Array
32296183
Intra
NCS1 P62166 SPP1 Homo sapiens P10451
Y2H Array
32296183
Intra
NCS1 P62166 SPP1 Homo sapiens P10451
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Validated Y2H
25416956
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Array
25416956
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Pooling
16189514
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H
21516116
Intra
NCS1 P62166 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NCS1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P86980 NCS1 Antibody (YA6673) WB Human, Mouse, Rat

関連疾患

Diseases Alias
Wolfram Syndrome

  • Didmoad Syndrome

  • Didmoad

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Wfs

  • Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

  • Didmoadud

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Wolfram Syndrome 2

  • WFS2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-N2037C (S)-Higenamine hydrobromide 97.85% Unkown
HY-122579 IGS-1.76 Inhibitor 98.57% Unkown
HY-N2037B (S)-Higenamine / Unkown
HY-RS09102 NCS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121503 FD44 / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus NCS1 RGD RGD:68417
Canis familiaris NCS1 VGNC VGNC:43667
Bos taurus NCS1 VGNC VGNC:31928
Felis catus NCS1 VGNC VGNC:63744
Mus musculus NCS1 MGD MGI:109166
Others NCS1 NCBI