METTL13 - methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Gene
Also Known as feat; DFNM1; CGI-01; DFNB26; DFNB26M; KIAA0859; EEF1AKNMT; 5630401D24Rik
生物種: Homo sapiens
About METTL13
This gene has 7 transcripts (splice variants), 207 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 10.7), lymph node (RPKM 7.3) and 25 other tissues.
Summary
Predicted to enable methyltransferase activity. Involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
METTL13 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001007239.2 | NP_001007240.1 | eEF1A lysine and N-terminal methyltransferase isoform 3 |
| NM_014955.3 | NP_055770.1 | eEF1A lysine and N-terminal methyltransferase isoform 2 |
| NM_015935.5 | NP_057019.3 | eEF1A lysine and N-terminal methyltransferase isoform 1 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21516116 | GOA |
| enables protein-lysine N-methyltransferase activity |
IDA
IDA: Inferred from direct assay
|
30143613 | GOA |
METTL13 Protein Structure
Methyltransf_11: Methyltransferase domain (53 - 157)
Methyltransf_18: Methyltransferase domain (497 - 614)
- 0
- 200
- 400
- 600
- 699 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
eEF1A lysine and N-terminal methyltransferase |
|
METTL13 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
METTL13 | Q8N6R0 | ATN1 | Homo sapiens | Q86V38 | 32814053 | |
|
Intra
|
METTL13 | Q8N6R0 | ATN1 | Homo sapiens | Q86V38 | 32814053 | |
|
Intra
|
METTL13 | Q8N6R0 | ATN1 | Homo sapiens | Q86V38 | 32814053 | |
|
Intra
|
METTL13 | Q8N6R0 | KLK6 | Homo sapiens | Q92876 | 32814053 | |
|
Intra
|
METTL13 | Q8N6R0 | KLK6 | Homo sapiens | Q92876 | 32814053 | |
|
Intra
|
METTL13 | Q8N6R0 | KLK6 | Homo sapiens | Q92876 | 32814053 | |
|
Intra
|
METTL13 | Q8N6R0 | VPS52 | Homo sapiens | Q8N1B4 | 25416956 | |
|
Intra
|
METTL13 | Q8N6R0 | VPS52 | Homo sapiens | Q8N1B4 | 25416956 | |
|
Intra
|
METTL13 | Q8N6R0 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
METTL13 | Q8N6R0 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
METTL13 | Q8N6R0 | SNRPA | Homo sapiens | P09012 | 25416956 | |
|
Intra
|
METTL13 | Q8N6R0 | SNRPA | Homo sapiens | P09012 | 25416956 | |
|
Intra
|
METTL13 | Q8N6R0 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
METTL13 | Q8N6R0 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
METTL13 | Q8N6R0 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
METTL13 | Q8N6R0 | THAP1 | Homo sapiens | Q9NVV9 | 21516116 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Deafness, Autosomal Recessive 26, Modifier Of |
|
|
| Autosomal Dominant Nonsyndromic Deafness 74 |
|
|
| Lung Cancer |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Macaca mulatta | METTL13 | VGNC | VGNC:72093 |
| Felis catus | METTL13 | VGNC | VGNC:61733 |
| Rattus norvegicus | METTL13 | RGD | RGD:1311526 |
| Bos taurus | METTL13 | VGNC | VGNC:31403 |
| Mus musculus | METTL13 | MGD | MGI:1918699 |
| Others | METTL13 | NCBI |