METTL13 - methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Gene

Also Known as feat; DFNM1; CGI-01; DFNB26; DFNB26M; KIAA0859; EEF1AKNMT; 5630401D24Rik

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51603

About METTL13

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,781,660-171,797,716 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 10.7), lymph node (RPKM 7.3) and 25 other tissues.

Summary

Predicted to enable methyltransferase activity. Involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL13 Products (3)

mRNA Protein Name
NM_001007239.2 NP_001007240.1 eEF1A lysine and N-terminal methyltransferase isoform 3
NM_014955.3 NP_055770.1 eEF1A lysine and N-terminal methyltransferase isoform 2
NM_015935.5 NP_057019.3 eEF1A lysine and N-terminal methyltransferase isoform 1
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: Inferred from direct assay
30143613 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL13 Protein Structure

Methyltransf_11

Methyltransf_11: Methyltransferase domain (53 - 157)

Methyltransf_18

Methyltransf_18: Methyltransferase domain (497 - 614)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
Protein Preferred Names Protein Names

eEF1A lysine and N-terminal methyltransferase

  • antiapoptotic protein FEAT

METTL13 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
METTL13 Q8N6R0 ATN1 Homo sapiens Q86V38 32814053
Intra
METTL13 Q8N6R0 ATN1 Homo sapiens Q86V38 32814053
Intra
METTL13 Q8N6R0 ATN1 Homo sapiens Q86V38 32814053
Intra
METTL13 Q8N6R0 KLK6 Homo sapiens Q92876 32814053
Intra
METTL13 Q8N6R0 KLK6 Homo sapiens Q92876 32814053
Intra
METTL13 Q8N6R0 KLK6 Homo sapiens Q92876 32814053
Intra
METTL13 Q8N6R0 VPS52 Homo sapiens Q8N1B4 25416956
Intra
METTL13 Q8N6R0 VPS52 Homo sapiens Q8N1B4 25416956
Intra
METTL13 Q8N6R0 TRAF2 Homo sapiens Q12933 32296183
Intra
METTL13 Q8N6R0 TRAF2 Homo sapiens Q12933 32296183
Intra
METTL13 Q8N6R0 SNRPA Homo sapiens P09012 25416956
Intra
METTL13 Q8N6R0 SNRPA Homo sapiens P09012 25416956
Intra
METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9 32296183
Intra
METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9 32296183
Intra
METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9 32296183
Intra
METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9
Y2H
21516116
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Deafness, Autosomal Recessive 26, Modifier Of
  • Deafness, Nonsyndromic, Modifier 1

  • DFNB26M

  • Dfnb26, Modifier Of

  • Dfnb26, Suppressor Of

  • Deafness, Nonsyndromic, Modifier Of, 1

  • Dfnm1

  • {Deafness, Autosomal Recessive 26, Modifier Of}

Autosomal Dominant Nonsyndromic Deafness 74
  • Dfna74

Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta METTL13 VGNC VGNC:72093
Felis catus METTL13 VGNC VGNC:61733
Rattus norvegicus METTL13 RGD RGD:1311526
Bos taurus METTL13 VGNC VGNC:31403
Mus musculus METTL13 MGD MGI:1918699
Others METTL13 NCBI