PPIL1 - peptidylprolyl isomerase like 1 Gene

Also Known as CYPL1; PCH14; hCyPX; PPIase; CGI-124

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51645

About PPIL1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:36,854,829-36,874,803 (from NCBI)

This gene has 2 transcripts (splice variants), 215 orthologues, 22 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 23.5), thyroid (RPKM 20.4) and 25 other tissues.

Summary

This gene is a member of the Cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and Infection of HIV-1 virions. Based on similarity to Other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

PPIL1 Products (1)

mRNA Protein Name
NM_016059.5 NP_057143.1 peptidyl-prolyl cis-trans isomerase-like 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
20007319 GOA
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
16595688 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16595688 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in embryonic brain development IMP
IMP: Inferred from mutant phenotype
33220177 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
33220177 GOA
involved in protein peptidyl-prolyl isomerization IDA
IDA: Inferred from direct assay
16595688 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIL1 Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (15 - 162)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase-like 1

  • cyclophilin like 1

PPIL1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PPIL1 Q9Y3C6 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
25416956
Intra
PPIL1 Q9Y3C6 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 PRR35 Homo sapiens P0CG20
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 PRR35 Homo sapiens P0CG20
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 SPDYE4 Homo sapiens A6NLX3
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 SPDYE4 Homo sapiens A6NLX3
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 LHX2 Homo sapiens P50458
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 LHX2 Homo sapiens P50458
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 N4BP2L2 Homo sapiens Q92802
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 N4BP2L2 Homo sapiens Q92802
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 COL17A1 Homo sapiens Q9UMD9
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 COL17A1 Homo sapiens Q9UMD9
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 CPSF6 Homo sapiens Q16630
Y2H Prey Pooling
25416956
Intra
PPIL1 Q9Y3C6 CPSF6 Homo sapiens Q16630
Validated Y2H
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Pull Down
20368803
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Pull Down
16595688
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Validated Y2H
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Array
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Anti Tag CoIP
33961781
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Anti Tag CoIP
28514442
Intra
PPIL1 Q9Y3C6 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 WDR83 Homo sapiens Q9BRX9
Y2H
22365833
Intra
PPIL1 Q9Y3C6 WDR83 Homo sapiens Q9BRX9
Anti Tag CoIP
33961781
Intra
PPIL1 Q9Y3C6 WDR83 Homo sapiens Q9BRX9
Anti Tag CoIP
22365833
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIL1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71226 PPIL1 Protein, Human (His) Q9Y3C6 (M1-G166) ≥ 90%, as determined by reducing SDS-PAGE.

PPIL1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P86275 PPIL1 Antibody (YA5967) WB, FC Human

関連疾患

Diseases Alias
Pontocerebellar Hypoplasia, Type 14

  • PCH14

  • Pontocerebellar Hypoplasia Type 14

  • Pontocerebellar Hypoplasia 14

  • Doid:0112325
Pontocerebellar Hypoplasia

  • Pch

  • Congenital Pontocerebellar Hypoplasia

  • Opch

  • Hypoplasia, Pontocerebellar

  • Pontoneocerebellar Hypoplasia

  • Nonsyndromic Pontocerebellar Hypoplasia
Spastic Quadriplegia

  • Spastic Quadriplegic Cerebral Palsy

  • Quadriplegic Infantile Cerebral Palsy

  • Tetraplegic Infantile Cerebral Palsy

  • Cerebral Palsy Spastic Quadriplegic

  • Quadriplegic Cerebral Palsy

  • Spastic Quadriplegia Cerebral Palsy

  • Spastic Tetraplegia Cerebral Palsy

  • Cerebral Palsy, Quadriplegic, Infantile

  • Cerebral Palsy With Spastic Tetraplegia

  • Congenital Spastic Quadriplegia

  • Spastic Tetraplegic Cerebral Palsy

  • Congenital Quadriplegia Nos

  • Tetraplegic Cerebral Palsy
Quadriplegia

  • Tetraplegia

  • Tetraplegias
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10954 PPIL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20084 Ppil1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26587 Ppil1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus PPIL1 VGNC VGNC:102486
Rattus norvegicus PPIL1 RGD RGD:1309119
Bos taurus PPIL1 VGNC VGNC:33201
Mus musculus PPIL1 MGD MGI:1916066
Macaca mulatta PPIL1 VGNC VGNC:104420
Canis familiaris PPIL1 VGNC VGNC:44855
Others PPIL1 NCBI