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NAGK - N-acetylglucosamine kinase Gene

Also Known as GNK; HSA242910

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 55577

About NAGK

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:71,068,296-71,079,808 (from NCBI)

This gene has 29 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in spleen (RPKM 27.6), esophagus (RPKM 26.3) and 25 other tissues.

Summary

This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]

NAGK Products (4)

mRNA	Protein	Name
NM_001330425.3	NP_001317354.1	N-acetyl-D-glucosamine kinase isoform 2
NM_001330426.2	NP_001317355.1	N-acetyl-D-glucosamine kinase isoform 2
NM_001365466.2	NP_001352395.1	N-acetyl-D-glucosamine kinase isoform 2
NM_017567.6	NP_060037.4	N-acetyl-D-glucosamine kinase isoform 1

NAGK Protein Structure

BcrAD_BadFG

0
100
200
300
344 a.a.

Protein Preferred Names	Protein Names
N-acetyl-D-glucosamine kinase	epididymis secretory sperm binding protein

NAGK Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	NAGK	Q9UJ70	ACTR10	Homo sapiens	Q9NZ32	Y2H Prey Pooling	25416956
Intra	NAGK	Q9UJ70	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	NAGK	Q9UJ70	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	25416956
Intra	NAGK	Q9UJ70	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	NAGK	Q9UJ70	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	NAGK	Q9UJ70	DACH1	Homo sapiens	Q9UI36	Y2H	21516116
Intra	NAGK	Q9UJ70	CDKN2C	Homo sapiens	P42773	Y2H Array	31515488
Intra	NAGK	Q9UJ70	CDKN2C	Homo sapiens	P42773	Y2H Prey Pooling	25416956
Intra	NAGK	Q9UJ70	CDKN2C	Homo sapiens	P42773	Validated Y2H	25416956
Intra	NAGK	Q9UJ70	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
Intra	NAGK	Q9UJ70	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	NAGK	Q9UJ70	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	NAGK	Q9UJ70	LNX1	Homo sapiens	Q8TBB1	Pull Down	16189514
Intra	NAGK	Q9UJ70	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	NAGK	Q9UJ70	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
Cross	NAGK	Q9UJ70	Snrpn	Rattus norvegicus	P63164	Anti Tag CoIP	37511433
Cross	NAGK	Q9UJ70	Snrpn	Rattus norvegicus	P63164	Pull Down	37511433

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Nonaka Myopathy	Gne Myopathy Hibm Distal Myopathy With Rimmed Vacuoles Hereditary Inclusion Body Myopathy Ibm2 Inclusion Body Myopathy, Quadriceps-Sparing Qsm Dmrv Distal Myopathy, Nonaka Type Inclusion Body Myopathy 2 Inclusion Body Myopathy, Autosomal Recessive NM Nonaka Distal Myopathy Myopathy, Distal, With Or Without Rimmed Vacuoles Inclusion Body Myopathy, Hereditary, Autosomal Recessive Inclusion Body Myopathy Type 2 Quadriceps-Sparing Myopathy Quadriceps Sparing Myopathy Rimmed Vacuole Myopathy Inclusion Body Myopathy 2, Autosomal Recessive, Formerly Ibm2, Formerly Hibm2 Hereditary Inclusion Body Myopathy Type 2 Inclusion Body Myopathy 2, Autosomal Recessive Myopathy, Distal, With Rimmed Vacuoles Inclusion Body Myopathy Autosomal Recessive Myopathy, Inclusion Body, Type 2 Myopathy, Nonaka
Sialuria	Sialuria, French Type French Type Sialuria Sialuria French Type Sialic Acid Storage Disease Sialic Acid Storage Disease, Finnish Type Infantile Sialic Acid Storage Disease
Chronic Monocytic Leukemia	Leukemia, Myeloid Leukemia, Monocytic, Chronic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-177554	KB05yne		99.97%	Unkown
HY-185414	KB05-Biotin		/	Unkown
HY-180637	N-Acetyl-L-glutamate 5-phosphate		/	Unkown
HY-RS09010	NAGK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20780	Nagk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27294	Nagk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	NAGK	RGD	RGD:1305057
Macaca mulatta	NAGK	VGNC	VGNC:74977
Bos taurus	NAGK	VGNC	VGNC:31868
Mus musculus	NAGK	MGD	MGI:1860418
Felis catus	NAGK	VGNC	VGNC:63713
Others	NAGK	NCBI