KIZ - kizuna centrosomal protein Gene

Also Known as RP69; HT013; Kizuna; PLK1S1; C20orf19; NCRNA00153

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 55857

About KIZ

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:21,125,975-21,246,622 (from NCBI)

This gene has 15 transcripts (splice variants), 179 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 20.1), ovary (RPKM 11.1) and 25 other tissues.

Summary

The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

KIZ Products (7)

mRNA Protein Name
NM_001163022.3 NP_001156494.1 centrosomal protein kizuna isoform 2
NM_001163023.3 NP_001156495.1 centrosomal protein kizuna isoform 3
NM_001276389.2 NP_001263318.1 centrosomal protein kizuna isoform 4
NM_001352434.2 NP_001339363.1 centrosomal protein kizuna isoform 5
NM_001352435.2 NP_001339364.1 centrosomal protein kizuna isoform 6
NM_001352436.2 NP_001339365.1 centrosomal protein kizuna isoform 7
NM_018474.6 NP_060944.3 centrosomal protein kizuna isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16980960 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16980960 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
16980960 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in centrosome IDA
IDA: Inferred from direct assay
16980960 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centrosomal protein kizuna

  • polo-like kinase 1 substrate 1

KIZ Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
KIZ Q2M2Z5 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
KIZ Q2M2Z5 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
KIZ Q2M2Z5 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
KIZ Q2M2Z5 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
25416956
Intra
KIZ Q2M2Z5 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
32296183
Intra
KIZ Q2M2Z5 TACC3 Homo sapiens Q9Y6A5
Y2H Array
25416956
Intra
KIZ Q2M2Z5 TACC3 Homo sapiens Q9Y6A5
Y2H Array
32296183
Intra
KIZ Q2M2Z5 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
25416956
Intra
KIZ Q2M2Z5 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
32296183
Intra
KIZ Q2M2Z5 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
KIZ Q2M2Z5 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
KIZ Q2M2Z5 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
KIZ Q2M2Z5 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
KIZ Q2M2Z5 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
KIZ Q2M2Z5 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
KIZ Q2M2Z5 CEP72 Homo sapiens Q9P209
Anti Bait CoIP
19536135
Intra
KIZ Q2M2Z5 CEP72 Homo sapiens Q9P209
IF
19536135
Intra
KIZ Q2M2Z5 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
KIZ Q2M2Z5 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Retinitis Pigmentosa 69

  • RP69

  • Retinitis Pigmentosa, Type 69
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Pica Disease

  • Pica
Preretinal Fibrosis

  • Cellophane Maculopathy

  • Macular Puckering Of Retina

  • Macular Retinal Puckering

  • Epiretinal Membrane
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07323 KIZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus KIZ MGD MGI:2684960
Rattus norvegicus KIZ RGD RGD:1307071
Canis familiaris KIZ VGNC VGNC:42424
Macaca mulatta KIZ VGNC VGNC:73838
Bos taurus KIZ VGNC VGNC:30620
Felis catus KIZ VGNC VGNC:63125
Others KIZ NCBI