EZR - ezrin Gene

Also Known as CVL; CVIL; VIL2; HEL-S-105

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 7430

About EZR

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:158,765,748-158,819,368 (from NCBI)

This gene has 3 transcripts (splice variants), 267 orthologues, 6 paralogues and is associated with 59 phenotypes. Ubiquitous expression in placenta (RPKM 124.6), small intestine (RPKM 120.8) and 25 other tissues.

Summary

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin Cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

EZR Products (2)

mRNA	Protein	Name
NM_001111077.2	NP_001104547.1	ezrin
NM_003379.5	NP_003370.2	ezrin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables ATPase binding	IPI IPI: Inferred from physical interaction	17825285	GOA
enables S100 protein binding	IPI IPI: Inferred from physical interaction	25554515	GOA
enables actin binding	IDA IDA: Inferred from direct assay	17825285	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	10793131	GOA
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12082081	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	23857773	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7844168	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	25554515	GOA
enables protein kinase A binding	IPI IPI: Inferred from physical interaction	25097019	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	10793131	GOA
involved in astral microtubule organization	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in cellular response to cAMP	IMP IMP: Inferred from mutant phenotype	17911601	GOA
involved in cortical microtubule organization	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in establishment of centrosome localization	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in establishment of endothelial barrier	IGI IGI: Inferred from genetic interaction	23264465	GOA
NOT involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in filopodium assembly	IMP IMP: Inferred from mutant phenotype	23106337	GOA
NOT involved in gland morphogenesis	IMP IMP: Inferred from mutant phenotype	24862762	GOA
involved in leukocyte cell-cell adhesion	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in membrane to membrane docking	IEP IEP: Inferred from expression pattern	12082081	GOA
involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	17911601	GOA
involved in negative regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in positive regulation of early endosome to late endosome transport	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in positive regulation of early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	21148287	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23264465	GOA
involved in positive regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in positive regulation of protein localization to early endosome	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in protein kinase A signaling	IMP IMP: Inferred from mutant phenotype	17911601	GOA
involved in protein localization to cell cortex	IMP IMP: Inferred from mutant phenotype	25554515	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	17825285	GOA
involved in protein-containing complex localization	IMP IMP: Inferred from mutant phenotype	20551903	GOA
NOT involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	20551903	GOA
NOT involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	22467863	GOA
NOT involved in regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	20551903	GOA
involved in regulation of organelle assembly	IGI IGI: Inferred from genetic interaction	21148287	GOA
involved in regulation of organelle assembly	IMP IMP: Inferred from mutant phenotype	21148287	GOA
involved in sphingosine-1-phosphate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23106337	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10793131	GOA
located in actin filament	IDA IDA: Inferred from direct assay	11598191	GOA
located in apical part of cell	IDA IDA: Inferred from direct assay	12082081	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17825285	GOA
located in cell periphery	IDA IDA: Inferred from direct assay	22291017	GOA
located in cell projection	IDA IDA: Inferred from direct assay	25889165	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23106337	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9852149	GOA
located in endosome	IDA IDA: Inferred from direct assay	21148287	GOA
located in filopodium	IDA IDA: Inferred from direct assay	12082081	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	21282464	GOA
colocalizes with immunological synapse	IDA IDA: Inferred from direct assay	17911601	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	20551903	GOA
located in microvillus	IDA IDA: Inferred from direct assay	12082081	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24862762	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7844168	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	17911601	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25097019	GOA
located in ruffle	IDA IDA: Inferred from direct assay	9852149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EZR Protein Structure

FERM_N

FERM_M

FERM_C

ERM

0
100
200
300
400
500
586 a.a.

Protein Preferred Names	Protein Names
ezrin	cytovillin 2

EZR Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	EZR	P15311	FES	Homo sapiens	P07332	CoIP	18046454
Intra	EZR	P15311	FES	Homo sapiens	P07332	Y2H	18046454
Intra	EZR	P15311	FES	Homo sapiens	P07332	IF	18046454
Intra	EZR	P15311	FES	Homo sapiens	P07332	Pull Down	18046454
Intra	EZR	P15311	FES	Homo sapiens	P07332	Anti Bait CoIP	18046454
Intra	EZR	P15311	EZR	Homo sapiens	P15311	Y2H	21988832
Intra	EZR	P15311	EZR	Homo sapiens	P15311	BioID	29568061
Intra	EZR	P15311	RDX	Homo sapiens	P35241	Anti Tag CoIP	26496610
Intra	EZR	P15311	NHERF1	Homo sapiens	O14745	BioID	29568061
Intra	EZR	P15311	EZR	Homo sapiens	P15311	FPS	31837246
Intra	EZR	P15311	EZR	Homo sapiens	P15311	Pull Down	11285285
Intra	EZR	P15311	EZR	Homo sapiens	P15311	Pull Down	29568061
Intra	EZR	P15311	RDX	Homo sapiens	P35241	Y2H Fragment Pooling	23414517
Intra	EZR	P15311	RDX	Homo sapiens	P35241	Anti Tag CoIP	33961781
Intra	EZR	P15311	RDX	Homo sapiens	P35241	BioID	29568061
Intra	EZR	P15311	RDX	Homo sapiens	P35241	Pull Down	29568061
Intra	EZR	P15311	NHERF1	Homo sapiens	O14745	Pull Down	20937695
Intra	EZR	P15311	NHERF1	Homo sapiens	O14745	Pull Down	11285285
Intra	EZR	P15311	RDX	Homo sapiens	P35241	Anti Tag CoIP	35271311
Intra	EZR	P15311	C2orf15	Homo sapiens	Q8WU43	Validated Y2H	32814053
Intra	EZR	P15311	C2orf15	Homo sapiens	Q8WU43	Y2H Pooling	32814053
Intra	EZR	P15311	C2orf15	Homo sapiens	Q8WU43	Y2H Array	32814053
Intra	EZR	P15311	SCYL3	Homo sapiens	Q8IZE3	Y2H	12651155
Intra	EZR	P15311	CAPN1	Homo sapiens	P07384	Protease Assay	22805611
Intra	EZR	P15311	KIRREL3	Homo sapiens	Q8IZU9	FPS	34799561
Intra	EZR	P15311	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32814053
Intra	EZR	P15311	THAP3	Homo sapiens	Q8WTV1	Y2H Pooling	32814053
Intra	EZR	P15311	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32814053
Intra	EZR	P15311	MISP	Homo sapiens	Q8IVT2	Y2H Prey Pooling	32296183
Intra	EZR	P15311	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	EZR	P15311	MISP	Homo sapiens	Q8IVT2	Y2H Array	32296183
Intra	EZR	P15311	MIER1	Homo sapiens	Q8N108-16	Validated Y2H	32814053
Intra	EZR	P15311	MIER1	Homo sapiens	Q8N108-16	Y2H Array	32814053
Intra	EZR	P15311	MIER1	Homo sapiens	Q8N108-16	Y2H Pooling	32814053
Intra	EZR	P15311	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	EZR	P15311	MDM2	Homo sapiens	Q00987	TAP	20195357
Intra	EZR	P15311	MDM2	Homo sapiens	Q00987	Display Tech	20195357
Intra	EZR	P15311	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EZR	P15311	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EZR	P15311	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EZR	P15311	S100A4	Homo sapiens	P26447	FPS	31837246
Intra	EZR	P15311	S100A2	Homo sapiens	P29034	FPS	31837246
Intra	EZR	P15311	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	EZR	P15311	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	EZR	P15311	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053
Cross	EZR	P15311	Dcc	Rattus norvegicus	Q63155	Pull Down	21849478
Cross	EZR	P15311	Dcc	Rattus norvegicus	Q63155	Anti Bait CoIP	21849478

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EZR Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70295	Ezrin/EZR Protein, Human	P15311 (M1-L586)	≥ 95%, as determined by reducing SDS-PAGE.

EZR 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80664	Ezrin Antibody (YA767)	WB	Human, Mouse, Rat
HY-P80664A	Ezrin Antibody (YA767)(PBS only)	WB	Human, Mouse, Rat
HY-P810624	Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody (YA9886)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P84111	Ezrin Antibody (YA3808)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P84111A	Ezrin Antibody (YA3808)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P86417	Ezrin Antibody (YA6109)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

関連疾患

Diseases	Alias
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neurinoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Hemangioblastoma	Capillary Hemangioblastoma
Kindler Syndrome	Poikiloderma Of Kindler Bullous Acrokeratotic Poikiloderma Of Kindler And Weary Congenital Bullous Poikiloderma KNDLRS Poikiloderma, Hereditary Acrokeratotic Poikiloderma, Congenital, With Bullae, Weary Type Kindler'S Syndrome Poikiloderma Congenital With Bullae Weary Type Hereditary Acrokeratotic Poikiloderma Of Kindler-Weary Hereditary Acrokeratotic Poikiloderma Weary Syndrome Poikiloderma Hereditary Acrokeratotic Potassium Deficiency
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Immunodeficiency 50	Combined Immunodeficiency Due To Moesin Deficiency IMD50 Immunodeficiency 50, X-Linked Recessive Cid Due To Moesin Deficiency Msn-Related Combined Immunodeficiency X-Linked Moesin-Associated Immunodeficiency Immunodeficiency 50 X Linked Recessive
Deafness, Autosomal Recessive 24	DFNB24 Deafness, Autosomal Recessive, 24 Autosomal Recessive Nonsyndromic Deafness 24 Autosomal Recessive Deafness 24 Deafness, Autosomal Recessive, Type 24
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Rhabdomyosarcoma
Childhood Osteosarcoma	Pediatric Osteosarcoma
Actinobacillosis
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Leukocyte Adhesion Deficiency, Type Iii	Leukocyte Adhesion Deficiency 3 LAD3 Leukocyte Adhesion Deficiency 1 Variant Lad1v Integrin Activation Deficiency Disease Iadd Leukocyte Adhesion Deficiency Type Iii Lad1 Variant Lad-1 Variant Lad-Iii Leukocyte Adhesion Deficiency-1 Variant Leukocyte Adhesion Deficiency Type 1
Chondroblastic Osteosarcoma	Chondrosarcomatous Osteogenic Sarcoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Microvillus Inclusion Disease	Congenital Microvillous Atrophy Intractable Diarrhea Of Infancy Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities Davidson Disease Microvillous Inclusion Disease Congenital Microvillus Atrophy Mvid Diarrhea 2 With Microvillus Atrophy Mvd Congenital Familial Protracted Diarrhea Davidson'S Disease Familial Enteropathy, Microvillus Microvillus Atrophy, Congenital Congenital Enteropathy Familial Protracted Enteropathy Microvillous Atrophy Microvillus Atrophy With Diarrhea 2 Idi
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa 50	RP50 Retinitis Pigmentosa, Concentric Retinitis Pigmentosa-50 Retinitis Pigmentosa Concentric
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Petrous Apex Meningioma	Meningioma Of The Petrous Ridge
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS04623	EZR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19860	Ezr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26360	Ezr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	EZR	MGD	MGI:98931
Bos taurus	EZR	VGNC	VGNC:28676
Felis catus	EZR	VGNC	VGNC:97426
Canis familiaris	EZR	VGNC	VGNC:40542
Macaca mulatta	EZR	VGNC	VGNC:72264
Rattus norvegicus	EZR	RGD	RGD:621161
Others	EZR	NCBI