製品番号: HY-14374

GPP78

(別名: CAY10618)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

GPP78 (CAY10618) is a potent Nampt inhibitor with an IC₅₀ of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC₅₀ of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.9%
CAS 番号: 1202580-59-3
分子式: C₂₇H₂₉N₅O
分子量:439.55

保管条件:

Solution, -20°C, 2 years

GPP78 構造式

CAS 番号: 1202580-59-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Nampt^[1];
Autophagy^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	7.33 μM Compound: 8	Growth inhibition of human 786-0 cells by sulforhodamine B assay Growth inhibition of human 786-0 cells by sulforhodamine B assay	[PMID: 19961183]
786-0	GI₅₀	7.33 x 10^-6 M Compound: 8	Growth inhibition of human 786-0 cells by sulforhodamine B assay Growth inhibition of human 786-0 cells by sulforhodamine B assay	[PMID: 19961183]
A498	GI₅₀	1.59 x 10^-5 M Compound: 8	Growth inhibition of human A498 cells by sulforhodamine B assay Growth inhibition of human A498 cells by sulforhodamine B assay	[PMID: 19961183]
A549	GI₅₀	2.1 μM Compound: 8	Growth inhibition of human A549 cells by sulforhodamine B assay Growth inhibition of human A549 cells by sulforhodamine B assay	[PMID: 19961183]
A549	GI₅₀	2.1 x 10^-6 M Compound: 8	Growth inhibition of human A549 cells by sulforhodamine B assay Growth inhibition of human A549 cells by sulforhodamine B assay	[PMID: 19961183]
ACHN	GI₅₀	1.87 x 10^-5 M Compound: 8	Growth inhibition of human ACHN cells by sulforhodamine B assay Growth inhibition of human ACHN cells by sulforhodamine B assay	[PMID: 19961183]
BT-549	GI₅₀	1.7 μM Compound: 8	Growth inhibition of human BT549 cells by sulforhodamine B assay Growth inhibition of human BT549 cells by sulforhodamine B assay	[PMID: 19961183]
BT-549	GI₅₀	1.7 x 10^-6 M Compound: 8	Growth inhibition of human BT549 cells by sulforhodamine B assay Growth inhibition of human BT549 cells by sulforhodamine B assay	[PMID: 19961183]
CAKI-1	GI₅₀	7.76 x 10^-7 M Compound: 8	Growth inhibition of human Caki1 cells by sulforhodamine B assay Growth inhibition of human Caki1 cells by sulforhodamine B assay	[PMID: 19961183]
CAKI-1	GI₅₀	7.76 x 10^-1 μM Compound: 8	Growth inhibition of human Caki1 cells by sulforhodamine B assay Growth inhibition of human Caki1 cells by sulforhodamine B assay	[PMID: 19961183]
CCRF-CEM	GI₅₀	3.28 μM Compound: 8	Growth inhibition of human CCRF-CEM cells by sulforhodamine B assay Growth inhibition of human CCRF-CEM cells by sulforhodamine B assay	[PMID: 19961183]
CCRF-CEM	GI₅₀	3.28 x 10^-6 M Compound: 8	Growth inhibition of human CCRF-CEM cells by sulforhodamine B assay Growth inhibition of human CCRF-CEM cells by sulforhodamine B assay	[PMID: 19961183]
COLO 205	GI₅₀	1.18 μM Compound: 8	Growth inhibition of human COLO205 cells by sulforhodamine B assay Growth inhibition of human COLO205 cells by sulforhodamine B assay	[PMID: 19961183]
COLO 205	GI₅₀	1.18 x 10^-6 M Compound: 8	Growth inhibition of human COLO205 cells by sulforhodamine B assay Growth inhibition of human COLO205 cells by sulforhodamine B assay	[PMID: 19961183]
DU-145	GI₅₀	7.02 x 10^-7 M Compound: 8	Growth inhibition of human DU145 cells by sulforhodamine B assay Growth inhibition of human DU145 cells by sulforhodamine B assay	[PMID: 19961183]
DU-145	GI₅₀	7.02 x 10^-1 μM Compound: 8	Growth inhibition of human DU145 cells by sulforhodamine B assay Growth inhibition of human DU145 cells by sulforhodamine B assay	[PMID: 19961183]
EKVX	GI₅₀	8.46 μM Compound: 8	Growth inhibition of human EKVX cells by sulforhodamine B assay Growth inhibition of human EKVX cells by sulforhodamine B assay	[PMID: 19961183]
EKVX	GI₅₀	8.46 x 10^-6 M Compound: 8	Growth inhibition of human EKVX cells by sulforhodamine B assay Growth inhibition of human EKVX cells by sulforhodamine B assay	[PMID: 19961183]
HCC 2998	GI₅₀	7 x 10^-7 M Compound: 8	Growth inhibition of human HCC2998 cells by sulforhodamine B assay Growth inhibition of human HCC2998 cells by sulforhodamine B assay	[PMID: 19961183]
HCC 2998	GI₅₀	7 x 10^-1 μM Compound: 8	Growth inhibition of human HCC2998 cells by sulforhodamine B assay Growth inhibition of human HCC2998 cells by sulforhodamine B assay	[PMID: 19961183]
HCT-116	GI₅₀	4.03 x 10^-8 M Compound: 8	Growth inhibition of human HCT116 cells by sulforhodamine B assay Growth inhibition of human HCT116 cells by sulforhodamine B assay	[PMID: 19961183]
HCT-116	GI₅₀	4.03 x 10^-2 μM Compound: 8	Growth inhibition of human HCT116 cells by sulforhodamine B assay Growth inhibition of human HCT116 cells by sulforhodamine B assay	[PMID: 19961183]
HCT-15	GI₅₀	2.57 x 10^-7 M Compound: 8	Growth inhibition of human HCT15 cells by sulforhodamine B assay Growth inhibition of human HCT15 cells by sulforhodamine B assay	[PMID: 19961183]
HCT-15	GI₅₀	2.57 x 10^-1 μM Compound: 8	Growth inhibition of human HCT15 cells by sulforhodamine B assay Growth inhibition of human HCT15 cells by sulforhodamine B assay	[PMID: 19961183]
HOP-62	GI₅₀	2.38 x 10^-5 M Compound: 8	Growth inhibition of human HOP62 cells by sulforhodamine B assay Growth inhibition of human HOP62 cells by sulforhodamine B assay	[PMID: 19961183]
HOP-92	GI₅₀	9.74 x 10^-5 M Compound: 8	Growth inhibition of human HOP92 cells by sulforhodamine B assay Growth inhibition of human HOP92 cells by sulforhodamine B assay	[PMID: 19961183]
Hs-578T	GI₅₀	2.04 x 10^-5 M Compound: 8	Growth inhibition of human Hs 578T cells by sulforhodamine B assay Growth inhibition of human Hs 578T cells by sulforhodamine B assay	[PMID: 19961183]
HT-29	GI₅₀	4.6 x 10^-7 M Compound: 8	Growth inhibition of human HT-29 cells by sulforhodamine B assay Growth inhibition of human HT-29 cells by sulforhodamine B assay	[PMID: 19961183]
HT-29	GI₅₀	4.6 x 10^-1 μM Compound: 8	Growth inhibition of human HT-29 cells by sulforhodamine B assay Growth inhibition of human HT-29 cells by sulforhodamine B assay	[PMID: 19961183]
IGROV-1	GI₅₀	2.72 x 10^-7 M Compound: 8	Growth inhibition of human IGROV1 cells by sulforhodamine B assay Growth inhibition of human IGROV1 cells by sulforhodamine B assay	[PMID: 19961183]
IGROV-1	GI₅₀	2.72 x 10^-1 μM Compound: 8	Growth inhibition of human IGROV1 cells by sulforhodamine B assay Growth inhibition of human IGROV1 cells by sulforhodamine B assay	[PMID: 19961183]
KM12	GI₅₀	1.03 μM Compound: 8	Growth inhibition of human KM12 cells by sulforhodamine B assay Growth inhibition of human KM12 cells by sulforhodamine B assay	[PMID: 19961183]
KM12	GI₅₀	1.03 x 10^-6 M Compound: 8	Growth inhibition of human KM12 cells by sulforhodamine B assay Growth inhibition of human KM12 cells by sulforhodamine B assay	[PMID: 19961183]
LOX IMVI	GI₅₀	1.01 x 10^-5 M Compound: 8	Growth inhibition of human LOXIMVI cells by sulforhodamine B assay Growth inhibition of human LOXIMVI cells by sulforhodamine B assay	[PMID: 19961183]
M14	GI₅₀	1.66 x 10^-7 M Compound: 8	Growth inhibition of human M14 cells by sulforhodamine B assay Growth inhibition of human M14 cells by sulforhodamine B assay	[PMID: 19961183]
M14	GI₅₀	1.66 x 10^-1 μM Compound: 8	Growth inhibition of human M14 cells by sulforhodamine B assay Growth inhibition of human M14 cells by sulforhodamine B assay	[PMID: 19961183]
Malme-3M	GI₅₀	1.22 x 10^-5 M Compound: 8	Growth inhibition of human MALME-3M cells by sulforhodamine B assay Growth inhibition of human MALME-3M cells by sulforhodamine B assay	[PMID: 19961183]
MCF7	GI₅₀	3.42 μM Compound: 8	Growth inhibition of human MCF7 cells by sulforhodamine B assay Growth inhibition of human MCF7 cells by sulforhodamine B assay	[PMID: 19961183]
MCF7	GI₅₀	3.42 x 10^-6 M Compound: 8	Growth inhibition of human MCF7 cells by sulforhodamine B assay Growth inhibition of human MCF7 cells by sulforhodamine B assay	[PMID: 19961183]
MDA-MB-231	GI₅₀	2.09 x 10^-5 M Compound: 8	Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay	[PMID: 19961183]
MDA-MB-435	GI₅₀	3.99 x 10^-7 M Compound: 8	Growth inhibition of human MDA-MB-435 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-435 cells by sulforhodamine B assay	[PMID: 19961183]
MDA-MB-435	GI₅₀	3.99 x 10^-1 μM Compound: 8	Growth inhibition of human MDA-MB-435 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-435 cells by sulforhodamine B assay	[PMID: 19961183]
MDA-MB-468	GI₅₀	7.34 μM Compound: 8	Growth inhibition of human MDA-MB-468 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-468 cells by sulforhodamine B assay	[PMID: 19961183]
MDA-MB-468	GI₅₀	7.34 x 10^-6 M Compound: 8	Growth inhibition of human MDA-MB-468 cells by sulforhodamine B assay Growth inhibition of human MDA-MB-468 cells by sulforhodamine B assay	[PMID: 19961183]
NCI/ADR-RES	GI₅₀	8.14 x 10^-8 M Compound: 8	Growth inhibition of human NCI/ADR-RES cells by sulforhodamine B assay Growth inhibition of human NCI/ADR-RES cells by sulforhodamine B assay	[PMID: 19961183]
NCI/ADR-RES	GI₅₀	8.14 x 10^-2 μM Compound: 8	Growth inhibition of human NCI/ADR-RES cells by sulforhodamine B assay Growth inhibition of human NCI/ADR-RES cells by sulforhodamine B assay	[PMID: 19961183]
NCI-H226	GI₅₀	1.55 x 10^-5 M Compound: 8	Growth inhibition of human NCI-H226 cells by sulforhodamine B assay Growth inhibition of human NCI-H226 cells by sulforhodamine B assay	[PMID: 19961183]
NCI-H23	GI₅₀	1.51 x 10^-5 M Compound: 8	Growth inhibition of human NCI-H23 cells by sulforhodamine B assay Growth inhibition of human NCI-H23 cells by sulforhodamine B assay	[PMID: 19961183]
NCI-H322M	GI₅₀	2.31 x 10^-5 M Compound: 8	Growth inhibition of human NCI-H322M cells by sulforhodamine B assay Growth inhibition of human NCI-H322M cells by sulforhodamine B assay	[PMID: 19961183]
NCI-H460	GI₅₀	7.24 x 10^-7 M Compound: 8	Growth inhibition of human NCI-H460 cells by sulforhodamine B assay Growth inhibition of human NCI-H460 cells by sulforhodamine B assay	[PMID: 19961183]
NCI-H460	GI₅₀	7.24 x 10^-1 μM Compound: 8	Growth inhibition of human NCI-H460 cells by sulforhodamine B assay Growth inhibition of human NCI-H460 cells by sulforhodamine B assay	[PMID: 19961183]
NCI-H522	GI₅₀	9.14 x 10^-8 M Compound: 8	Growth inhibition of human NCI-H522 cells by sulforhodamine B assay Growth inhibition of human NCI-H522 cells by sulforhodamine B assay	[PMID: 19961183]
NCI-H522	GI₅₀	9.14 x 10^-2 μM Compound: 8	Growth inhibition of human NCI-H522 cells by sulforhodamine B assay Growth inhibition of human NCI-H522 cells by sulforhodamine B assay	[PMID: 19961183]
OVCAR-3	GI₅₀	5.19 μM Compound: 8	Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay	[PMID: 19961183]
OVCAR-3	GI₅₀	5.19 x 10^-6 M Compound: 8	Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay	[PMID: 19961183]
OVCAR-4	GI₅₀	3.16 x 10^-5 M Compound: 8	Growth inhibition of human OVCAR4 cells by sulforhodamine B assay Growth inhibition of human OVCAR4 cells by sulforhodamine B assay	[PMID: 19961183]
OVCAR-5	GI₅₀	2.68 x 10^-7 M Compound: 8	Growth inhibition of human OVCAR5 cells by sulforhodamine B assay Growth inhibition of human OVCAR5 cells by sulforhodamine B assay	[PMID: 19961183]
OVCAR-5	GI₅₀	2.68 x 10^-1 μM Compound: 8	Growth inhibition of human OVCAR5 cells by sulforhodamine B assay Growth inhibition of human OVCAR5 cells by sulforhodamine B assay	[PMID: 19961183]
OVCAR-8	GI₅₀	5.74 x 10^-8 M Compound: 8	Growth inhibition of human OVCAR8 cells by sulforhodamine B assay Growth inhibition of human OVCAR8 cells by sulforhodamine B assay	[PMID: 19961183]
OVCAR-8	GI₅₀	5.74 x 10^-2 μM Compound: 8	Growth inhibition of human OVCAR8 cells by sulforhodamine B assay Growth inhibition of human OVCAR8 cells by sulforhodamine B assay	[PMID: 19961183]
PC-3	GI₅₀	4.67 x 10^-7 M Compound: 8	Growth inhibition of human PC3 cells by sulforhodamine B assay Growth inhibition of human PC3 cells by sulforhodamine B assay	[PMID: 19961183]
PC-3	GI₅₀	4.67 x 10^-1 μM Compound: 8	Growth inhibition of human PC3 cells by sulforhodamine B assay Growth inhibition of human PC3 cells by sulforhodamine B assay	[PMID: 19961183]
RXF 393	GI₅₀	1 x 10^-4 M Compound: 8	Growth inhibition of human RXF393 cells by sulforhodamine B assay Growth inhibition of human RXF393 cells by sulforhodamine B assay	[PMID: 19961183]
SF-268	GI₅₀	2.47 x 10^-5 M Compound: 8	Growth inhibition of human SF268 cells by sulforhodamine B assay Growth inhibition of human SF268 cells by sulforhodamine B assay	[PMID: 19961183]
SF-295	GI₅₀	6.55 x 10^-7 M Compound: 8	Growth inhibition of human SF295 cells by sulforhodamine B assay Growth inhibition of human SF295 cells by sulforhodamine B assay	[PMID: 19961183]
SF-295	GI₅₀	6.55 x 10^-1 μM Compound: 8	Growth inhibition of human SF295 cells by sulforhodamine B assay Growth inhibition of human SF295 cells by sulforhodamine B assay	[PMID: 19961183]
SF-539	GI₅₀	6.18 x 10^-8 M Compound: 8	Growth inhibition of human SF539 cells by sulforhodamine B assay Growth inhibition of human SF539 cells by sulforhodamine B assay	[PMID: 19961183]
SF-539	GI₅₀	6.18 x 10^-2 μM Compound: 8	Growth inhibition of human SF539 cells by sulforhodamine B assay Growth inhibition of human SF539 cells by sulforhodamine B assay	[PMID: 19961183]
SH-SY5Y	IC₅₀	3 nM Compound: 8	Cytotoxicity against human SH-SY5Y cells assessed as reduction of total cellular NAD(P) level Cytotoxicity against human SH-SY5Y cells assessed as reduction of total cellular NAD(P) level	[PMID: 19961183]
SH-SY5Y	IC₅₀	3.8 nM Compound: 8	Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 19961183]
SH-SY5Y	IC₅₀	3.8 nM Compound: 5	Cytotoxicity against human SH-SY5Y cells Cytotoxicity against human SH-SY5Y cells	[PMID: 21080724]
SK-MEL-2	GI₅₀	1.28 x 10^-5 M Compound: 8	Growth inhibition of human SK-MEL-2 cells by sulforhodamine B assay Growth inhibition of human SK-MEL-2 cells by sulforhodamine B assay	[PMID: 19961183]
SK-MEL-28	GI₅₀	1.59 μM Compound: 8	Growth inhibition of human SK-MEL-28 cells by sulforhodamine B assay Growth inhibition of human SK-MEL-28 cells by sulforhodamine B assay	[PMID: 19961183]
SK-MEL-28	GI₅₀	1.59 x 10^-6 M Compound: 8	Growth inhibition of human SK-MEL-28 cells by sulforhodamine B assay Growth inhibition of human SK-MEL-28 cells by sulforhodamine B assay	[PMID: 19961183]
SK-MEL-5	GI₅₀	2.64 x 10^-5 M Compound: 8	Growth inhibition of human SK-MEL-5 cells by sulforhodamine B assay Growth inhibition of human SK-MEL-5 cells by sulforhodamine B assay	[PMID: 19961183]
SK-OV-3	GI₅₀	2.05 x 10^-5 M Compound: 8	Growth inhibition of human SKOV3 cells by sulforhodamine B assay Growth inhibition of human SKOV3 cells by sulforhodamine B assay	[PMID: 19961183]
SN12C	GI₅₀	4.26 x 10^-8 M Compound: 8	Growth inhibition of human SN12C cells by sulforhodamine B assay Growth inhibition of human SN12C cells by sulforhodamine B assay	[PMID: 19961183]
SN12C	GI₅₀	4.26 x 10^-2 μM Compound: 8	Growth inhibition of human SN12C cells by sulforhodamine B assay Growth inhibition of human SN12C cells by sulforhodamine B assay	[PMID: 19961183]
SNB-19	GI₅₀	4.5 x 10^-7 M Compound: 8	Growth inhibition of human SNB19 cells by sulforhodamine B assay Growth inhibition of human SNB19 cells by sulforhodamine B assay	[PMID: 19961183]
SNB-19	GI₅₀	4.5 x 10^-1 μM Compound: 8	Growth inhibition of human SNB19 cells by sulforhodamine B assay Growth inhibition of human SNB19 cells by sulforhodamine B assay	[PMID: 19961183]
SNB-75	GI₅₀	2.98 x 10^-5 M Compound: 8	Growth inhibition of human SNB75 cells by sulforhodamine B assay Growth inhibition of human SNB75 cells by sulforhodamine B assay	[PMID: 19961183]
SW-620	GI₅₀	6.15 x 10^-8 M Compound: 8	Growth inhibition of human SW620 cells by sulforhodamine B assay Growth inhibition of human SW620 cells by sulforhodamine B assay	[PMID: 19961183]
SW-620	GI₅₀	6.15 x 10^-2 μM Compound: 8	Growth inhibition of human SW620 cells by sulforhodamine B assay Growth inhibition of human SW620 cells by sulforhodamine B assay	[PMID: 19961183]
T47D	GI₅₀	1.23 μM Compound: 8	Growth inhibition of human T47D cells by sulforhodamine B assay Growth inhibition of human T47D cells by sulforhodamine B assay	[PMID: 19961183]
T47D	GI₅₀	1.23 x 10^-6 M Compound: 8	Growth inhibition of human T47D cells by sulforhodamine B assay Growth inhibition of human T47D cells by sulforhodamine B assay	[PMID: 19961183]
TK-10	GI₅₀	1.82 x 10^-5 M Compound: 8	Growth inhibition of human TK10 cells by sulforhodamine B assay Growth inhibition of human TK10 cells by sulforhodamine B assay	[PMID: 19961183]
U-251	GI₅₀	5.21 x 10^-7 M Compound: 8	Growth inhibition of human U251 cells by sulforhodamine B assay Growth inhibition of human U251 cells by sulforhodamine B assay	[PMID: 19961183]
U-251	GI₅₀	5.21 x 10^-1 μM Compound: 8	Growth inhibition of human U251 cells by sulforhodamine B assay Growth inhibition of human U251 cells by sulforhodamine B assay	[PMID: 19961183]
UACC-257	GI₅₀	1.33 x 10^-5 M Compound: 8	Growth inhibition of human UACC257 cells by sulforhodamine B assay Growth inhibition of human UACC257 cells by sulforhodamine B assay	[PMID: 19961183]
UACC-62	GI₅₀	1.33 x 10^-5 M Compound: 8	Growth inhibition of human UACC62 cells by sulforhodamine B assay Growth inhibition of human UACC62 cells by sulforhodamine B assay	[PMID: 19961183]
UO-31	GI₅₀	1.69 x 10^-5 M Compound: 8	Growth inhibition of human UO31 cells by sulforhodamine B assay Growth inhibition of human UO31 cells by sulforhodamine B assay	[PMID: 19961183]

体外実験

GPP78 (Compound 8; 10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes^[1].
GPP78 (Compound 8) inhibits the growth of most cell lines tested, with nanomolar potency (GI₅₀) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SH-SY5Y cells
Concentration:

10 nM
Incubation Time:

24 hours, 40 hours
Result:

Punctate staining of LC3-II and the formation of autophagolysosomes were observable.

体内実験

GPP78 (10 mg/kg; intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment reduces the severity of spinal cord trauma in SCI mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male adult CD1 mice (25-30 g) with spinal cord injury (SCI)^[2]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days
Result:

Significantly reduced the demyelination associated with SCI. And significantly ameliorated the functional deficits induced by SCI.

化学情報

CAS 番号 1202580-59-3
性状 Liquid
分子量 439.55
分子式 C₂₇H₂₉N₅O
Color Colorless to light yellow
SMILES

O=C(CCCCCCCN1N=NC(C2=CN=CC=C2)=C1)NC3=CC=CC=C3C4=CC=CC=C4
別名

CAY10618
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Solution, -20°C, 2 years

Publications (1)

All

Sort by:

Journal Impact Factor

Sci Signal

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. [Abstract]

2021 Jun 8;14(686):eabc7405. PMID: 34103421

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53(2):616-23. [Content Brief]

[2]. Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012 Apr 10;9:66. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

GPP78

1 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

GPP78

MedChemExpress（MCE）の使用を引用している文献 GPP78

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

GPP78 関連分類

HY-14374 関連分類