GR 82334
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 129623-01-4
- 分子式: C69H91N15O16
- 分子量:1386.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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![[Sar9,Met(O2)11]-Substance P](https://file.medchemexpress.com/product_pic/hy-p1012.gif)
HY-P1012
[Sar9,Met(O2)11]-Substance PTachykinin NK1 Receptor Agonist -
HY-P1198
Hemokinin 1, humanNeurokinin Receptor Agonist -
HY-P1194
Spantide INK1 Receptor Antagonist -
HY-P1192
GR-73632NK1 Receptor Agonist -
HY-14407A
Fosaprepitant dimeglumineNeurokinin-1 Receptor Antagonist -
HY-14406A
L-733060 hydrochlorideNK1 Receptor Antagonist -
HY-108483
RP 67580NK1 Receptors Antagonist, Substance P Antagonist -
HY-108482
CP-96,345NK-1 Receptor Antagonist -
HY-101249
L-732138NK-1 Receptor Antagonist -
HY-P1030
Hemokinin 1 (mouse)Neurokinin 1 Receptor Agonist -
HY-108481
L-760735NK1 receptor antagonist -
HY-14407
FosaprepitantNeurokinin-1 Receptor Antagonist
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2]
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Dosage:10 nM, 100 nM, and 1 µM
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Administration:Lntrathecal injection between vertebrae L4 and L5
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Result:Increased heat-induced foot withdrawal latency in mice.
化学情報
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CAS 番号 129623-01-4
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分子量 1386.55
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分子式 C69H91N15O16
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配列
{Glp}-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-{d-Pro(spiro-γ-lactam)Leu}-Trp-NH2
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シーケンスの短縮
{Glp}-ADPNKFY-{d-Pro(spiro-γ-lactam)Leu}-W-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci [Content Brief]
[2]. Antje Brand, et al. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GR 82334 関連分類
HY-P1193 関連分類
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