GRP75-IN-1
GRP75-IN-1 (Compound 33) is an anti-endometrial cancer (EC) agent. GRP75-IN-1 induces apoptosis in endometrial cancer cells. GRP75-IN-1 hydrochloride reduces mitochondrial Ca2+ levels by targeting GRP75 and disrupting its interaction with IP3R. GRP75-IN-1 inhibits tumor growth in human endometrial cancer xenograft animal models. GRP75-IN-1 can be used for research in endometrial cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2922680-16-6
- 分子式: C27H38N4OS
- 分子量:466.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Ishikawa | IC50 |
0.99 μM
Compound: 33
|
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 39082833] |
| KLE | IC50 |
3.18 μM
Compound: 33
|
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 39082833] |
化学情報
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CAS 番号 2922680-16-6
-
分子量 466.68
-
分子式 C27H38N4OS
-
SMILES
CN1CCC2(CCN(CC2)CCCCCN3C4=C(SC5=CC=C(C=C53)OC)C=CC=N4)CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)