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製品番号: HY-187166

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Hamiformamide

Hamiformamide is a nitric oxide production inhibitor with an IC₅₀ of 49.1 μM, which is isolated from Hamigera avellanea IFM 52957. Hamiformamide inhibits nitric oxide production in macrophage-like cells. Hamiformamide modulates host immune signals.

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CAS 番号: 179419-82-0
分子式: C₁₉H₁₈N₂O₄
分子量:338.36

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hamiformamide 構造式

CAS 番号: 179419-82-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NO Synthase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A498	IC₅₀	1.72 μM Compound: 4	Cytotoxicity against human A498 cells Cytotoxicity against human A498 cells	[PMID: 21667925]
ACHN	IC₅₀	1.37 μM Compound: 4	Cytotoxicity against human ACHN cells Cytotoxicity against human ACHN cells	[PMID: 21667925]
HOP-92	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human HOP92 cells Cytotoxicity against human HOP92 cells	[PMID: 21667925]
Malme-3M	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human MALME-3M cells Cytotoxicity against human MALME-3M cells	[PMID: 21667925]
MOLT-4	IC₅₀	1.81 μM Compound: 4	Cytotoxicity against human MOLT4 cells Cytotoxicity against human MOLT4 cells	[PMID: 21667925]
NCI-H460	IC₅₀	1.84 μM Compound: 4	Cytotoxicity against human NCI-H460 cells Cytotoxicity against human NCI-H460 cells	[PMID: 21667925]
SF-295	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human SF295 cells Cytotoxicity against human SF295 cells	[PMID: 21667925]
SK-MEL-28	IC₅₀	2.03 μM Compound: 4	Cytotoxicity against human SK-MEL-28 cells Cytotoxicity against human SK-MEL-28 cells	[PMID: 21667925]
SK-MEL-5	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human SK-MEL-5 cells Cytotoxicity against human SK-MEL-5 cells	[PMID: 21667925]
SK-OV-3	IC₅₀	2.13 μM Compound: 4	Cytotoxicity against human SKOV3 cells Cytotoxicity against human SKOV3 cells	[PMID: 21667925]
U-251	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human U251 cells Cytotoxicity against human U251 cells	[PMID: 21667925]
UACC-62	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human UACC62 cells Cytotoxicity against human UACC62 cells	[PMID: 21667925]

体外実験

Hamiformamide (5-100 μM; 2 h pre-incubation, 24 h incubation with LPS) potently inhibits LPS-induced nitric oxide production in RAW264 macrophage-like cells with an IC₅₀ of 49.1 µM while maintaining high cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 179419-82-0
分子量 338.36
分子式 C₁₉H₁₈N₂O₄
SMILES

COC1=CC=C(/C=C(NC=O)/C(NC=O)=C/C2=CC=C(O)C=C2)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Saito S, et al. Activation of hamiformamide production in the thermotolerant fungus Hamigera avellanea triggered by co-culture with animal immune cells. J Antibiot (Tokyo). 2026 Jul 1. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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