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United States

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製品番号: HY-P12121

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HB43

HB43 is a synthetic amphipathic cationic α-helical peptide, as well as an antibacterial/anticancer peptide. HB43 reduces the number of Methicillin (HY-121544)-resistant Staphylococcus aureus in biofilms in a dose-dependent manner. When loaded into chitosan nanoparticles, it achieves sustained release, and this effect is particularly pronounced under acidic conditions.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 932013-61-1
分子式: C₇₂H₁₂₉N₁₇O₁₄
分子量:1456.90

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

HB43 構造式

CAS 番号: 932013-61-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

HB43 exhibits anti-cancer activity against MCF-7, SW480, BMKC, H1299, HeLa S3 and PC-3 cells. The LD₅₀ of HB43 for these cells ranges from 6 to 15 μg/mL^[1].
HB43 (108-216 μg/mL; 24 h), either free or loaded in P1-CNP, reduces MRSA USA300 LAC biofilm bacterial load and biomass in a dose-dependent manner; P1-CNP-loaded HB43 exhibits superior antibiofilm activity compared to free HB43, with the highest efficacy observed under acidic (pH 5.5) conditions^[2].
HB43 (108-216 μg/mL; 24 h) disrupts the membrane integrity of MRSA USA300 LAC biofilm-embedded bacteria in a dose-dependent manner, with the highest membrane damage observed at 216 μg/mL^[2].
HB43 (216 μg/mL; 2-4 h) penetrates MRSA USA300 LAC biofilms within 2 h and shows extensive uniform distribution across the biofilm surface by 4 h^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 932013-61-1
分子量 1456.90
分子式 C₇₂H₁₂₉N₁₇O₁₄
SMILES

N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
配列

Phe-Ala-Lys-Leu-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Leu
シーケンスの短縮

FAKLLAKLAKKLL
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Herrera-León C, et al. The impact of phosphatidylserine exposure on cancer cell membranes on the activity of the anticancer peptide HB43. The FEBS journal. 2022 Apr;289(7):1984-2003. [Content Brief]

[2]. Keikhosravani P, et al. Developing antibacterial HB43 peptide-loaded chitosan nanoparticles for biofilm treatment. International journal of biological macromolecules. 2025 May;310(Pt 2):143397. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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