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製品番号: HY-W162231

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HC102A

HC102A is an Antibacterial agent and an inhibitor of DosS and DosT histidine sensor kinases, with an IC₅₀ of 1.9 μM against Mycobacterium tuberculosis DosS. HC102A does not alter the heme redox state of sensor kinases. HC102A reduces triacylglycerol synthesis and accumulation, decreases the survival rate of Mtb under non-replicating persistent and hypoxic conditions, and enhances the sensitivity of Mtb to Isoniazid (HY-B0329). HC102A can be used in research related to tuberculosis.

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CAS 番号: 91216-38-5
分子式: C₁₁H₁₈N₂O₂
分子量:210.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

HC102A 構造式

CAS 番号: 91216-38-5

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Bacterial InfectionLipid MetabolismOthers

Bacterial Infection

HC102A (0.01-100 μM) potently and selectively inhibits DosR-dependent GFP fluorescence in Mtb CDC1551 (hspX′::GFP), with an EC₅₀ of 12.4 μM^[1].
HC102A (1 h) directly inhibits autophosphorylation of purified Mtb DosS protein with an IC₅₀ of 1.9 μM, but has minimal effect on autophosphorylation of DosT^[1].
HC102A (1-100 μM; 10 days) reduces the survival rates of Mtb CDC1551 and Erdman strains in a dose-dependent manner under hypoxic NRP conditions, and decreases the strain survival rate by approximately 50% at a dose of 10 μM^[1].
HC102A inhibits the autokinase activity of DosS and DosT histidine kinases in *Mycobacterium tuberculosis*, reduces the hypoxia-induced survival rate of *Mycobacterium tuberculosis*, and exhibits extremely low cytotoxicity against mammalian cell lines^[3].

Bacterial Infection

Lipid Metabolism

HC102A (40 μM; 6 days) reduces TAG accumulation by 67% in Mtb CDC1551, thereby disrupting a key lipid metabolic process associated with persistence^[1].

Others

HC102A directly inhibits the autophosphorylation activity of the Mycobacterium tuberculosis DosS sensor kinase, but exerts no such effect on the DosT sensor kinase^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 91216-38-5
分子量 210.28
分子式 C₁₁H₁₈N₂O₂
SMILES

O=C1NC(=O)C2(N1)CC(C)CC(C)(C)C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zheng H, et al. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nature chemical biology. 2017 Feb;13(2):218-225. [Content Brief]

[2]. Johnson BK, et al. Small Molecules That Sabotage Bacterial Virulence. Trends in pharmacological sciences. 2017 Apr;38(4):339-362. [Content Brief]

[3]. Stupar M, et al. Two-component sensor histidine kinases of Mycobacterium tuberculosis: Beacons for niche navigation. Molecular microbiology. 2022 May;117(5):973-985. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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