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製品番号: HY-165396

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HC103A

HC103A is an Antibacterial agent and a DosS/DosT histidine sensor kinase inhibitor, with an IC₅₀ of 0.5 μM against DosS and ~5 μM against DosT of *Mycobacterium tuberculosis*. HC103A inhibits the autophosphorylation of DosS/DosT. HC103A suppresses hypoxia-induced triacylglycerol synthesis and the viability of Mtb. HC103A can be used in the research of tuberculosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 312595-37-2
分子式: C₁₈H₁₄N₂O₃S
分子量:338.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

HC103A 構造式

CAS 番号: 312595-37-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

HC103A (0.1-100 μM; 6 d) potently and selectively inhibits DosR-dependent GFP fluorescence in Mycobacterium tuberculosis CDC1551(hspX′::GFP) with an EC₅₀ of 2.7 μM without affecting bacterial growth^[1].
HC103A (40 μM) reduces triacylglycerol accumulation by 56% in Mycobacterium tuberculosis CDC1551, disrupting a key persistence-associated lipid metabolism pathway^[1].
HC103A (0-60 μM; 1 h) directly inhibits autophosphorylation of purified Mycobacterium tuberculosis DosS (IC₅₀ 0.5 μM) and DosT (IC₅₀ ~5 μM) sensor kinases without altering their heme redox status^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 312595-37-2
分子量 338.38
分子式 C₁₈H₁₄N₂O₃S
SMILES

O=C(NC1=CC=CC(=C1)C(=O)NC=2C=CC=C(O)C2)C=3SC=CC3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zheng H, et al. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol. 2017;13(2):218-225. [Content Brief]

[2]. Zheng H, et al. Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme. ACS Chem Biol. 2020 Jan 17;15(1):52-62. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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