country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-175473

Copy Link Print Information

HI042

HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC₅₀ values of 0.62 μM for MOLM-13, 0.33 μM for MV4-11, and 0.89 μM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication (FLT3-|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 898168-15-5
分子式: C₁₄H₁₁N₃O₃S
分子量:301.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HI042 構造式

CAS 番号: 898168-15-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

FLT3

体外実験

HI042 shows IC₅₀ values for MOLM-13 cells were 0.88, 0.52, and 0.36 μM and >40, 1.03, and 0.64 μM for MV4-11 cells for the periods of 24, 48, and 72 h, respectively^[1].
HI042 (0.3-5 μM, 7-10 days) reduces autonomous clonal growth in MOLM-13 and MV4-11 cells^[1].
HI042 (0.25-4 μM, 72 h) induces cell apoptosis and disrupts in MOLM-13 and MV4-11 cells^[1].
HI042 (0.25-1 μM, 72 h) induces cell differentiation in MOLM-13 and MV4-11 cells^[1].
HI042 (0.06-1 μM, 72 h) significantly reduces the viability companied with Quizartinib (HY-13001) (0.12-2 nM) in MOLM-13 and MV4-11 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MOLM-13 and MV4-11 cells
Concentration:

0.312, 0.625, 1.25, 2.5, 5, 10, 20, and 40 μM
Incubation Time:

24, 48 and 72 h
Result:

Reduced cell viability in a time- and concentration dependent manner.

Apoptosis Analysis^[1]

Cell Line:

MOLM-13 and MV4-11 cells
Concentration:

0.25, 0.5 1, 2 and 4 μM
Incubation Time:

72 h
Result:

Increased the _SubG1 cell population.
Increased PARP1 cleavage and γH2AX expression.

Cell Differentiation Assay^[1]

Cell Line:

MOLM-13 and MV4-11 cells
Concentration:

0.25, 0.5 and 1 μM
Incubation Time:

72 h
Result:

Increased CD11b-positive cells.
Increased expression of the genes CEBPA and CEBPB.

化学情報

CAS 番号 898168-15-5
分子量 301.32
分子式 C₁₄H₁₁N₃O₃S
SMILES

O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)/C=C/C2=CC=CC=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. de Miranda LBL, et al. Screening for Antileukemia Agents in FMS-like Tyrosine Kinase 3 (FLT3)-Mutated Acute Myeloid Leukemia Cells. ACS Pharmacol Transl Sci. 2025 Jul 22;8(8):2756-2766. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ