Histargin
Histargin is a selective carboxypeptidase B inhibitor with an IC50 of 17 μg/mL and a Ki of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 93361-66-1
- 分子式: C14H25N7O4
- 分子量:355.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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carboxypeptidase B 17 μg/mL (IC50) |
carboxypeptidase B 30 μM (Ki) |
Histargin monohydrate (30 min) potently and competitively inhibits purified bovine carboxypeptidase B with an IC50 of 17 μg/mL and a Ki of 3.2 × 10-5 M, and this inhibitory activity is dependent on metal chelation, being blocked by specific divalent metal cations[1].
Histargin does not inhibit purified carboxypeptidase A, aminopeptidase A (IC50 >100 μg/mL)[1].
Histargin lacks antimicrobial activity at 100 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 93361-66-1
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分子量 355.39
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分子式 C14H25N7O4
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SMILES
N=C(N)NCCC[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC1=CN=CN1
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Structure Classification
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Initial Source
Streptomyces roseoviridis
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Histargin 関連分類
HY-122369 関連分類
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