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製品番号: HY-122369

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Histargin

Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B.

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CAS 番号: 93361-66-1
分子式: C₁₄H₂₅N₇O₄
分子量:355.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Histargin 構造式

CAS 番号: 93361-66-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

carboxypeptidase B

17 μg/mL (IC₅₀)

carboxypeptidase B

30 μM (Ki)

体外実験

Histargin monohydrate (30 min) potently and competitively inhibits purified bovine carboxypeptidase B with an IC₅₀ of 17 μg/mL and a K_i of 3.2 × 10^-5 M, and this inhibitory activity is dependent on metal chelation, being blocked by specific divalent metal cations^[1].
Histargin does not inhibit purified carboxypeptidase A, aminopeptidase A (IC50 >100 μg/mL)^[1].
Histargin lacks antimicrobial activity at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 93361-66-1
分子量 355.39
分子式 C₁₄H₂₅N₇O₄
SMILES

N=C(N)NCCC[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC1=CN=CN1
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Streptomyces roseoviridis
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. UMEZAWA H, et al. Histargin, a new inhibitor of carboxypeptidase B, produced by actinomycetes[J]. The Journal of Antibiotics, 1984, 37(9): 1088-1090.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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