HJ-PI01
Based on 2 publication(s) in Google Scholar
HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.50%
- CAS 番号: 6192-43-4
- 分子式: C14H11NO2
- 分子量:225.24
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 HJ-PI01
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
>30 μM
Compound: 13a
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Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by Neubauer counting chamber analysis
Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by Neubauer counting chamber analysis
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[PMID: 26708110] |
| MDA-MB-231 | IC50 |
300 nM
Compound: 63; HJ-PI01
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Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
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[PMID: 33650861] |
HJ-PI01 (0-3200 nmol/L; 48 hours) dose-dependently inhibits MDA-MB-231 cell growth and shows a substantial improvement compared with chlorpromazine and PI003[1]. HJ-PI01 (100-400 nmol/L; 24 hours) shows weak toxicity to normal non-cancer cells[1]. HJ-PI01 (300 nmol/L; 24 hours) induces autophagic cell death of MDA-MB-231 cells[1]. HJ-PI01 (300 nmol/L; 24 hours) induces apoptotic cell death in MDA-MB-231 cells[1]. HJ-PI01 (300 and 460 nmol/L; 12-48 hours) affects the expression levels of autophagy and apoptosis-related proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cell line
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Concentration:300 and 460 nmol/L
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Incubation Time:12, 24, 36 and 48 hours
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Result:Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c female nude mice with MDA-MB-231 cells injection[1]
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Dosage:40 mg/kg
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Administration:Oral administration; 40 mg/kg, once daily for 10 days
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Result:Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.
化学情報
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CAS 番号 6192-43-4
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性状 Solid
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分子量 225.24
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分子式 C14H11NO2
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Color White to off-white
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SMILES
CC(N1C2=C(C=CC=C2)OC3=CC=CC=C13)=O
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別名
10-Acetylphenoxazine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Mol Immunol
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming. [Abstract]2025 Apr;22(4):418-436. PMID: 40000906 -
Phytomedicine
Colchicine alleviates atherosclerosis combined with diabetes mellitus by targeting PIM2 and regulating the NF-κB signaling pathway. [Abstract]2025 Nov:147:157194. PMID: 40865347
溶剤 & 溶解度
DMSO : 50 mg/mL (221.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4397 mL | 22.1985 mL | 44.3971 mL | 110.9927 mL |
| 5 mM | 0.8879 mL | 4.4397 mL | 8.8794 mL | 22.1985 mL | |
| 10 mM | 0.4440 mL | 2.2199 mL | 4.4397 mL | 11.0993 mL | |
| 15 mM | 0.2960 mL | 1.4799 mL | 2.9598 mL | 7.3995 mL | |
| 20 mM | 0.2220 mL | 1.1099 mL | 2.2199 mL | 5.5496 mL | |
| 25 mM | 0.1776 mL | 0.8879 mL | 1.7759 mL | 4.4397 mL | |
| 30 mM | 0.1480 mL | 0.7400 mL | 1.4799 mL | 3.6998 mL | |
| 40 mM | 0.1110 mL | 0.5550 mL | 1.1099 mL | 2.7748 mL | |
| 50 mM | 0.0888 mL | 0.4440 mL | 0.8879 mL | 2.2199 mL | |
| 60 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8499 mL | |
| 80 mM | 0.0555 mL | 0.2775 mL | 0.5550 mL | 1.3874 mL | |
| 100 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL | 1.1099 mL |
HJ-PI01 関連分類
HY-129163 関連分類
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