Human CES2 Enzyme
Based on 1 Customer Validation
Human CES2 Enzyme is a carboxylesterase involved in drug metabolism and lipid homeostasis. Human CES2 Enzyme hydrolyzes triglycerides, cholesteryl esters and retinyl esters to regulate lipid metabolism and energy homeostasis. Human CES2 Enzyme improves glucose tolerance and insulin sensitivity, reduces hepatic lipid accumulation, alleviates white adipose tissue steatitis, decreases plasma cholesterol levels, and reduces body weight and white adipose tissue weight. Human CES2 Enzyme can be used in the research of metabolic syndrome.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.00%
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:FVB/NRj mice (4-60 weeks old) with global Ces2 cluster knockout and liver- or intestine-specific human CES2 transgenic modification on Ces2-/- background[1]
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Dosage:/
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Administration:/
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Result:Significantly reduced the elevated plasma AUC and tissue concentration of capecitabine in global Ces2 cluster knockout mice.
Alleviated fatty liver, adipositis, hypercholesterolemia, impaired glucose tolerance and insulin sensitivity caused by Ces2 deficiency, but increased liver size, adipose tissue mass and total body weight (Hepatic).
Effectively rescued all metabolic syndrome phenotypes and even improved some indicators such as body weight compared with wild-type mice (Intestinal).
化学情報
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SMILES
[Human CES2 Enzyme]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)