Indusatumab
Based on 1 Customer Validation
Indusatumab (5F9 Monoclonal antibody) is a monoclonal antibody against human GUCY2C (Guanylate cyclase 2C). Indusatumab fails to bind to granulocytes or erythrocytes. Indusatumab can be used to synthesize ADCs, such as Indusatumab vedotin (HY-P99662). Indusatumab can be used in cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: ≥99.0%
- CAS 番号: 1497400-26-6
- 分子量:145.206 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Human IgG1 kappa
Human
GUCY2C
Indusatumab fails to bind to granulocytes or erythrocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Loaded Indusatumab on AHC2 biosensor, can bind GUCY2C/Guanylyl cyclase C Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77944) with an affinity constant of 2.157E-08 M as determined in BLI assay. -
Immobilized Hu-GUCY2C-his can bind Indusatumab. The EC50 for this effect is 4.769 ng/mL.
化学情報
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CAS 番号 1497400-26-6
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性状 Liquid
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分子量 145.206 kDa
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Color Colorless to light yellow
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SMILES
[Indusatumab]
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別名
5F9 Monoclonal antibody; TAK-164 Antibody
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. e Goeij BE, et al. New developments for antibody-drug conjugate-based therapeutic approaches. Curr Opin Immunol. 2016 Jun;40:14-23. [Content Brief]
[2]. Khazaeli MB, et al. Development and characterization of a monoclonal antibody to human embryonal carcinoma. J Urol. 1987 Jun;137(6):1295-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)