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製品番号: HY-W305227

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INN-312

INN-312 is a sickle hemoglobin (Hb S) inhibitor capable of penetrating red blood cell membranes. INN-312 inhibits sickling of sickle red blood cells under hypoxic conditions, increases the oxygen affinity of Hb, and moderately improves the solubility of deoxygenated Hb S. INN-312 can be used in research related to sickle cell disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 923255-75-8
分子式: C₁₄H₁₃NO₃
分子量:243.26

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

INN-312 構造式

CAS 番号: 923255-75-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

INN-312 (0.5-2 mM) dose-dependently inhibits sickling of sickle erythrocytes (SS cells) under hypoxic conditions at 37°C, with 81% inhibition at 2 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

INN-312 (50-150 mg/kg; i.p.; single dose) produces dose-dependent increases in AUC_0-t and C_max in transgenic sickle mice, with consistent pharmacokinetic parameters across doses, and strongly shifts hemoglobin OEC leftward^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Transgenic sickle mice^[1]
Dosage:

50 mg/kg; 100 mg/kg; 150 mg/kg
Administration:

i.p.; single dose
Result:

Produced AUC values of 314 µg/mL/min, 648 µg/mL/min, and 1044 µg/mL/min for 50, 100, and 150 mg/kg doses, respectively.
Showed terminal half-life of 0.75 h, peak concentration time of 0.5 h, and mean resident time of 1.2 h, consistent across all dosage groups.
Increased maximum plasma concentration in a dose-dependent manner.
Shifted hemoglobin oxygen equilibrium curve toward the left more strongly than various previously reported compounds.

化学情報

CAS 番号 923255-75-8
分子量 243.26
分子式 C₁₄H₁₃NO₃
SMILES

O=CC1=CC(OC)=CC=C1OCC=2C=NC=CC2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Abdulmalik, O. Y., et al. (2005). In Vitro Antisickling Effects of Novel Pyridyl Derivatives with Enhanced Potency. Blood, 106(11), 2347.

[2]. Abdulmalik O, et al. VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions. Scientific reports. 2020 Nov 20;10(1):20277. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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