Insecticidal agent 33
Insecticidal agent 33 is an AChE inhibitor with nematicidal activity. Insecticidal agent 33 impairs locomotor activity of Caenorhabditis elegans, and induces oxidative damage in Caenorhabditis elegans, including elevated reactive oxygen species (ROS) levels, lipofuscin accumulation, lipid deposition, and disrupted cellular homeostasis. Insecticidal agent 33 can be used for the research of plant-parasitic nematode infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H15N3O3S
- 分子量:389.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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AChE |
Insecticidal agent 33 (compound A18) (48 h) potently kills Caenorhabditis elegans with an LC50 of 4.19 mg/L, achieving 100% nematicidal activity[1].
Insecticidal agent 33 (48 h) exhibits 65.5% nematicidal activity against Bursaphelenchus xylophilus[1].
Insecticidal agent 33 (48 h) kills Meloidogyne incognita with an LC50 of 21.15 mg/L, achieving 79.6% nematicidal activity that is comparable to positive control Tioxazafen (HY-136240)[1].
Insecticidal agent 33 (50 mg/L) potently inhibits acetylcholinesterase activity in Caenorhabditis elegans[1].
Insecticidal agent 33 binds to the active pocket of acetylcholinesterase via hydrogen bonds with residues Phe-288, Arg-289, and Ser-286, supporting its potent inhibitory activity against the enzyme[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C. elegans[1]
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Dosage:5; 10; 12.5; 20; 25; 30; 40; 50; 100 mg/L
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Administration:single treatment
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Result:Dose-dependently impaired locomotor activity of C. elegans.
Induced oxidative damage.
Elevated reactive oxygen species (ROS) levels, lipofuscin accumulation, lipid deposition, and disrupted cellular homeostasis.
化学情報
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分子量 389.43
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分子式 C21H15N3O3S
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SMILES
COC1=CC=C2C(N=C(CO2)C3=CC=C(C=C3)C4=NOC(C5=CC=CS5)=N4)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Insecticidal agent 33 関連分類
HY-183949 関連分類
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- Insecticidal agent 33
- Insecticidal agent33
- Insecticidal agent-33
- Insecticide
- Cholinesterase (ChE)
- Reactive Oxygen Species (ROS)
- oxidative damage
- Meloidogyne incognita
- Bursaphelenchus xylophilus
- oxidative stress
- plant-parasitic nematode infection
- reactive oxygen species
- acetylcholinesterase
- tomato seedlings
- Caenorhabditis elegans
- lipofuscin
- Inhibitor
- inhibitor
- inhibit