IPI-269609
IPI-269609 is an orally effective Smoothed (SMO) inhibitor that targets the Hedgehog (Hh) signaling pathway. IPI-269609 specifically reduces the ALDH-bright (high aldehyde dehydrogenase activity) cell subset, which is considered the "cancer stem cells" in pancreatic cancer. IPI-269609 significantly inhibits the migration and colony formation of pancreatic cancer cells. IPI-269609 effectively inhibits pancreatic cancer metastasis in a mouse model. IPI-269609 can be used for pancreatic cancer research.
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- CAS 番号: 878204-96-7
- 分子式: C28H41NO2
- 分子量:423.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3H 10T1/2 | EC50 |
0.2 μM
Compound: 9
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Inhibition of Hedgehog pathway-dependent oxysterol-induced mouse C3 H10T1/2 cell differentiation assessed as alkaline phosphatase production after 72 hrs
Inhibition of Hedgehog pathway-dependent oxysterol-induced mouse C3 H10T1/2 cell differentiation assessed as alkaline phosphatase production after 72 hrs
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[PMID: 18842035] |
| C3H 10T1/2 | EC50 |
0.3 μM
Compound: 2, IPI-269609
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Inhibition of HedgeHog pathway in mouse C3H10T1/2 cells assessed as inhibition of 20-(S)-hydroxysterol/22-(S)-hydroxysterol-induced osteoblastic differentiation after 72 hrs by Gli-luc reporter assay
Inhibition of HedgeHog pathway in mouse C3H10T1/2 cells assessed as inhibition of 20-(S)-hydroxysterol/22-(S)-hydroxysterol-induced osteoblastic differentiation after 72 hrs by Gli-luc reporter assay
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[PMID: 19522463] |
| C3H 10T1/2 | EC50 |
200 nM
Compound: 18, (IPI-269609/IPI-609)
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Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay
Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay
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[PMID: 19309080] |
| C3H 10T1/2 | EC50 |
200 nM
Compound: 7, IPI-609
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Inhibition of SHH-mediated mouse C3H10T1/2 cell differentiation to osteoblasts
Inhibition of SHH-mediated mouse C3H10T1/2 cell differentiation to osteoblasts
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10.1039/C3MD00334E |
化学情報
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CAS 番号 878204-96-7
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分子量 423.63
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分子式 C28H41NO2
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SMILES
O=C1CC[C@]2(C)[C@@]3([H])CC4=C(C)C[C@]([C@@H]5C)(CC[C@@]4([H])[C@]3([H])CCC2=C1)O[C@@]6([H])[C@@]5([H])NC[C@@H](C)C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
IPI-269609 関連分類
HY-13654 関連分類
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