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United States

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製品番号: HY-186309

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ISRACT-01

ISRACT-01 is an integrated stress response (ISR) activator. ISRACT-01 has a K_d of 557 nM for eIF2B^Δ-latch. ISRACT-01 cooperates with eIF2-P to inhibit guanine nucleotide exchange factor (GEF) activity by specifically binding to and stabilizing the inactive conformation (I-state) of eIF2B. ISRACT-01 can be used in studies related to amyotrophic lateral sclerosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₀H₃₂Cl₂N₂O₄
分子量:555.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ISRACT-01 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

eIF2BΔ-latch

557 nM (Kd)

体外実験

ISRACT-01 (2.4 μM; 5 days) protects BJ fibroblasts treated with Tunicamycin (HY-A0098) from apoptosis^[1].
ISRACT-01 (2-10 μM; 30 min-3 h) inhibits polyribosome formation and promotes the accumulation of ATF4 protein expression in wild-type mouse fibroblasts^[1].
The K_d value for the binding of FAM-ISRACT-01 (2.5 nM; 30 min) to the eIF2B^Δ-latch decamer is 557 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

BJ fibroblasts
Concentration:

2.4 μM (pre-incubation concentration 3 μM)
Incubation Time:

Pre-incubated for 4 h, recorded over 5 days
Result:

Protected the cells from tunicamycin-induced apoptosis.

Western Blot Analysis^[1]

Cell Line:

Wild-type mouse embryonic fibroblasts (MEFs, Eif2s1 S51/S51)
Concentration:

2 μM, 10 μM
Incubation Time:

3 h
Result:

Significantly increased the expression level of ATF4 protein.

化学情報

分子量 555.49
分子式 C₃₀H₃₂Cl₂N₂O₄
SMILES

O=C(CCOC1=CC=C(Cl)C=C1)N[C@H]2CC[C@H](N(CC3=CC=CC=C3)C(COC4=CC=C(Cl)C=C4)=O)CC2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dalwadi U, et al. Allosteric disordering of eIF2B regulates the integrated stress response. Nature chemical biology. 2026 Jun 29.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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