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United States

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製品番号: HY-N10404

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Junceellolide C

Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC₅₀ values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 121769-82-2
分子式: C₂₆H₃₃ClO₁₀
分子量:540.99

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Junceellolide C 構造式

CAS 番号: 121769-82-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	CC₅₀	>50 μM Compound: 31	Cytotoxicity against C57BL/6 mouse BMDM cells incubated for 48 hrs by MTT assay Cytotoxicity against C57BL/6 mouse BMDM cells incubated for 48 hrs by MTT assay	[PMID: 36446206]
HepG2	CC₅₀	>100 μM Compound: 27	Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay	[PMID: 32690259]

体外実験

Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC₅₀ values of 2.27, 3.52 μM, respectively^[1].
Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepAD38 cells
Concentration:

10 μM
Incubation Time:

72 h, 8 days
Result:

Inhibited cccDNA transcription.

化学情報

CAS 番号 121769-82-2
分子量 540.99
分子式 C₂₆H₃₃ClO₁₀
SMILES

C[C@@]12[C@]([C@@H]([C@]3([C@@]([C@H](C(/C=C\[C@@H]2OC(C)=O)=C)Cl)([H])OC([C@@H]3C)=O)O)OC(C)=O)([H])[C@]4(CC[C@@H]1OC(C)=O)CO4
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Animals
South China Sea gorgonian Dichotella gemmacea
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jiru Wu, et al. Briarane-type diterpenoids from a gorgonian coral Ellisella sp. with anti-HBV activities. Bioorg Chem. 2020 Dec;105:104423. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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