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製品番号: HY-123141

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K00135

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Based on 1 Customer Validation

K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.03%
CAS 番号: 869650-21-5
分子式: C₁₈H₁₈N₄O
分子量:306.36

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

K00135 構造式

CAS 番号: 869650-21-5

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Fluorescent Dye

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生物活性

製品説明

K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets^[1].

Pim アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	8 μM Compound: K00135	Growth inhibition of human K562 cells after 48 hrs by WST-1 assay Growth inhibition of human K562 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
MOLM-13	IC₅₀	0.3 μM Compound: K00135	Growth inhibition of human MOLM13 cells after 48 hrs by WST-1 assay Growth inhibition of human MOLM13 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
MV4-11	IC₅₀	0.4 μM Compound: K00135	Growth inhibition of human MV4-11 cells after 48 hrs by WST-1 assay Growth inhibition of human MV4-11 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
RS4-11	IC₅₀	8.8 μM Compound: K00135	Growth inhibition of human RS4:11 cells after 48 hrs by WST-1 assay Growth inhibition of human RS4:11 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
SEM	IC₅₀	6 μM Compound: K00135	Growth inhibition of human SEM cells after 48 hrs by WST-1 assay Growth inhibition of human SEM cells after 48 hrs by WST-1 assay	[PMID: 22136433]

化学情報

CAS 番号 869650-21-5
性状 Solid
分子量 306.36
分子式 C₁₈H₁₈N₄O
Color Light yellow to light brown
SMILES

CC(C1=CC=CC(C2=CN=C3C=CC(NCC4CC4)=NN32)=C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 11.67 mg/mL (38.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2641 mL

16.3207 mL

32.6413 mL

5 mM

0.6528 mL

3.2641 mL

6.5283 mL

10 mM

0.3264 mL

1.6321 mL

3.2641 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Pogacic V, et al. Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity[J]. Cancer research, 2007, 67(14): 6916-6924.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2641 mL	16.3207 mL	32.6413 mL	81.6033 mL
	5 mM	0.6528 mL	3.2641 mL	6.5283 mL	16.3207 mL
	10 mM	0.3264 mL	1.6321 mL	3.2641 mL	8.1603 mL
	15 mM	0.2176 mL	1.0880 mL	2.1761 mL	5.4402 mL
	20 mM	0.1632 mL	0.8160 mL	1.6321 mL	4.0802 mL
	25 mM	0.1306 mL	0.6528 mL	1.3057 mL	3.2641 mL
	30 mM	0.1088 mL	0.5440 mL	1.0880 mL	2.7201 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
化学情報
溶剤 & 溶解度
- 体外実験
純度とドキュメンテーション
参考文献

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K00135

MCE Bioactive Compound Library

Pim アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

K00135 関連分類

HY-123141 関連分類