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製品番号: HY-117167

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KB-141

KB-141 is a potent and selective TRβ agonist. The IC₅₀ values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 219691-94-8
分子式: C₁₇H₁₆Cl₂O₄
分子量:355.21

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (241 KB)

KB-141 構造式

CAS 番号: 219691-94-8

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生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
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生物活性

製品説明

IC₅₀ & Target

219691-94-8

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	0.78 nM Compound: 2a	Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay	[PMID: 17543524]
CHO-K1	EC₅₀	1.7 nM Compound: 2a	Activity against TRAF-alpha-1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay Activity against TRAF-alpha-1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay	[PMID: 17543524]
CHO-K1	EC₅₀	11 nM Compound: 15	Effect on CHO-K1 cells stably transfected with Thyroid hormone receptor alpha (TRalpha1) and an alkaline phosphate reporter gene downstream thyroid response element TRAF-alpha1 was determined Effect on CHO-K1 cells stably transfected with Thyroid hormone receptor alpha (TRalpha1) and an alkaline phosphate reporter gene downstream thyroid response element TRAF-alpha1 was determined	[PMID: 12699376]
CHO-K1	EC₅₀	3.5 nM Compound: 15	Effect on CHO-K1 cells stably transfected with Thyroid hormone receptor beta and an alkaline phosphate reporter gene downstream thyroid response element TRAF-beta1 was determined Effect on CHO-K1 cells stably transfected with Thyroid hormone receptor beta and an alkaline phosphate reporter gene downstream thyroid response element TRAF-beta1 was determined	[PMID: 12699376]
CHO-K1	IC₅₀	1.1 nM Compound: 2a	Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells	[PMID: 17543524]
CHO-K1	IC₅₀	25 nM Compound: 2a	Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells	[PMID: 17543524]
CV-1	EC₅₀	1.12 nM Compound: 2, KB-141	Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells by TRE-luciferase assay Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells by TRE-luciferase assay	[PMID: 18585912]
CV-1	EC₅₀	4.5 nM Compound: 2, KB-141	Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells by TRE-luciferase assay Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells by TRE-luciferase assay	[PMID: 18585912]

化学情報

CAS 番号 219691-94-8
分子量 355.21
分子式 C₁₇H₁₆Cl₂O₄
SMILES

O=C(CC1=CC(Cl)=C(C(Cl)=C1)OC2=CC=C(C(C(C)C)=C2)O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.