L48H37
Based on 1 publication(s) in Google Scholar
L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.13%
- CAS 番号: 343307-76-6
- 分子式: C27H33NO7
- 分子量:483.55
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 L48H37
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生物活性
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TLR4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
4.2 μM
Compound: 7B
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 29655083] |
| HEp-2 | IC50 |
16.59 μM
Compound: 569; CA15
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Antiproliferative activity against human HEp-2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human HEp-2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 32172081] |
| HEp-2 | IC50 |
16.59 μM
Compound: 179
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Cytotoxicity against human Hep2 Cells
Cytotoxicity against human Hep2 Cells
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[PMID: 31129455] |
| L02 | IC50 |
12.8 μM
Compound: 7B
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Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 29655083] |
| L02 | IC50 |
46.79 μM
Compound: 569; CA15
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Antiproliferative activity against human HL7702 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human HL7702 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 32172081] |
| L02 | IC50 |
46.79 μM
Compound: 179
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Cytotoxicity against human HL-7702 cells
Cytotoxicity against human HL-7702 cells
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[PMID: 31129455] |
| NCI-H1650 | IC50 |
8.2 μM
Compound: 7B
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Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 29655083] |
| NCI-H1975 | IC50 |
6.5 μM
Compound: 7B
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Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 29655083] |
| NCI-H460 | IC50 |
4.9 μM
Compound: 7B
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Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 29655083] |
L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages[1].L48H37 (0-20?μM; 24 hours) decreases the viability of A549 and H460 cells with IC50 values of 5.3?μM and 2.3?μM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC50?of 21?μM[2].L48H37 (1, 2, or 4?μM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells[2].L48H37 (4?μM; 16?hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and H460 cells; BEAS-2B cells
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Concentration:0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM
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Incubation Time:24 hours
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Result:Inhibited lung cancer cells growth in a concentration-dependent manner.
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Cell Line:A549 and H460 cells
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Concentration:0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM
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Incubation Time:24 hours
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Result:Decreased p‐Cdc2, Cdc2, and Bcl‐2 expression in 2 lung cancer cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g)[2]
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Dosage:5 mg or 10 mg/kg
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Administration:Intraperitoneal injection; once daily; 11‐day
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Result:Reduced tumor wet weights as compared to vehicle control. Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo.Exhibited no significant structural changes in mice.
化学情報
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CAS 番号 343307-76-6
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性状 Solid
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分子量 483.55
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分子式 C27H33NO7
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Color Light yellow to yellow
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SMILES
O=C1/C(CN(C/C1=C\C2=CC(OC)=C(C(OC)=C2)OC)CC)=C/C3=CC(OC)=C(C(OC)=C3)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 50 mg/mL (103.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yi Wang, et al. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50 [Content Brief]
[2]. Chen Feng, et al. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0680 mL | 10.3402 mL | 20.6804 mL | 51.7010 mL |
| 5 mM | 0.4136 mL | 2.0680 mL | 4.1361 mL | 10.3402 mL | |
| 10 mM | 0.2068 mL | 1.0340 mL | 2.0680 mL | 5.1701 mL | |
| 15 mM | 0.1379 mL | 0.6893 mL | 1.3787 mL | 3.4467 mL | |
| 20 mM | 0.1034 mL | 0.5170 mL | 1.0340 mL | 2.5850 mL | |
| 25 mM | 0.0827 mL | 0.4136 mL | 0.8272 mL | 2.0680 mL | |
| 30 mM | 0.0689 mL | 0.3447 mL | 0.6893 mL | 1.7234 mL | |
| 40 mM | 0.0517 mL | 0.2585 mL | 0.5170 mL | 1.2925 mL | |
| 50 mM | 0.0414 mL | 0.2068 mL | 0.4136 mL | 1.0340 mL | |
| 60 mM | 0.0345 mL | 0.1723 mL | 0.3447 mL | 0.8617 mL | |
| 80 mM | 0.0259 mL | 0.1293 mL | 0.2585 mL | 0.6463 mL | |
| 100 mM | 0.0207 mL | 0.1034 mL | 0.2068 mL | 0.5170 mL |
L48H37 関連分類
HY-126154 関連分類
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